| Literature DB >> 6508756 |
E D Saggerson, M I Bird, C A Carpenter, K A Winter, J J Wright.
Abstract
Starvation (24h) increased the maximum activity of carnitine palmitoyltransferase 1 in rat liver and increased the concentration of malonyl-CoA required to cause 50% inhibition of the enzyme (I50). Re-feeding (24h) with a standard cube diet or a high-carbohydrate diet reversed both of these changes, whereas re-feeding with a high-fat diet did not. Administration of cycloheximide (200 micrograms/100 g body wt.) blocked the increases in carnitine palmitoyltransferase 1 activity and I50 on starvation. It is suggested that increase in carnitine palmitoyltransferase 1 activity in starvation may involve synthesis of new enzyme.Entities:
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Year: 1984 PMID： 6508756 PMCID： PMC1144414 DOI： 10.1042/bj2240201
Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857