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Literature DB >> 7126192

Sensitivity of carnitine acyltransferase I to malonly-CoA inhibition in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration in vivo.

Abstract

The sensitivity of carnitine acyltransferase I (EC 2.3.1.21) activity to malonyl-CoA inhibition in rat liver mitochondria isolated from animals in various physiological states was quantitatively proportional to the hepatic malonyl-CoA concentration in vivo. It is suggested that this relationship between the two parameters could result in a potent amplification mechanism for the reciprocal regulation of fatty acid synthesis and oxidation.

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Year: 1982 PMID： 7126192 PMCID： PMC1158567 DOI： 10.1042/bj2060177

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

10 in total

1. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

Review 2. Regulation of hepatic fatty acid oxidation and ketone body production.

Authors: J D McGarry; D W Foster
Journal: Annu Rev Biochem Date: 1980 Impact factor: 23.643

3. Differential inhibition of ketogenesis by malonyl-CoA in mitochondria from fed and starved rats.

Authors: G A Cook; D A Otto; N W Cornell
Journal: Biochem J Date: 1980-12-15 Impact factor: 3.857

4. Evaluation of malonyl-CoA in the regulation of long-chain fatty acid oxidation in the liver. Evidence for an unidentified regulatory component of the system.

Authors: J A Ontko; M L Johns
Journal: Biochem J Date: 1980-12-15 Impact factor: 3.857

5. Acylation of carnitine and glycerophosphate in suspensions of rat liver mitochondria at varying levels of palmitate and coenzyme A.

Authors: B Borrebaek
Journal: Acta Physiol Scand Date: 1975-12

6. The effect of glucagon treatment and starvation of virgin and lactating rats on the rates of oxidation of octanoyl-L-carnitine and octanoate by isolated liver mitochondria.

Authors: V A Zammit
Journal: Biochem J Date: 1980-08-15 Impact factor: 3.857

7. Characteristics of fatty acid oxidation in rat liver homogenates and the inhibitory effect of malonyl-CoA.

Authors: J D McGarry; G P Mannaerts; D W Foster
Journal: Biochim Biophys Acta Date: 1978-09-28

8. Regulation of hepatic fatty acid metabolism. The activities of mitochondrial and microsomal acyl-CoA:sn-glycerol 3-phosphate O-acyltransferase and the concentrations of malonyl-CoA, non-esterified and esterified carnitine, glycerol 3-phosphate, ketone bodies and long-chain acyl-CoA esters in livers of fed or starved pregnant, lactating and weaned rats.

Authors: V A Zammit
Journal: Biochem J Date: 1981-07-15 Impact factor: 3.857

9. Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats.

Authors: J D McGarry; D W Foster
Journal: Biochem J Date: 1981-11-15 Impact factor: 3.857

10. The role of malonyl-coa in the coordination of fatty acid synthesis and oxidation in isolated rat hepatocytes.

Authors: J D McGarry; Y Takabayashi; D W Foster
Journal: J Biol Chem Date: 1978-11-25 Impact factor: 5.157

10 in total

41 in total

1. Sensitivity of inhibition of rat liver mitochondrial outer-membrane carnitine palmitoyltransferase by malonyl-CoA to chemical- and temperature-induced changes in membrane fluidity.

Authors: M P Kolodziej; V A Zammit
Journal: Biochem J Date: 1990-12-01 Impact factor: 3.857

2. Changes in the properties of cytosolic acetyl-CoA carboxylase studied in cold-clamped liver samples from fed, starved and starved-refed rats.

Authors: A M Moir; V A Zammit
Journal: Biochem J Date: 1990-12-01 Impact factor: 3.857

3. The role of changes in the sensitivity of hepatic mitochondrial overt carnitine palmitoyltransferase in determining the onset of the ketosis of starvation in the rat.

Authors: L Drynan; P A Quant; V A Zammit
Journal: Biochem J Date: 1996-09-15 Impact factor: 3.857

4. Evidence that the sensitivity of carnitine palmitoyltransferase I to inhibition by malonyl-CoA is an important site of regulation of hepatic fatty acid oxidation in the fetal and newborn rabbit. Perinatal development and effects of pancreatic hormones in cultured rabbit hepatocytes.

Authors: C Prip-Buus; J P Pegorier; P H Duee; C Kohl; J Girard
Journal: Biochem J Date: 1990-07-15 Impact factor: 3.857

Review 5. Role of insulin in hepatic fatty acid partitioning: emerging concepts.

Authors: V A Zammit
Journal: Biochem J Date: 1996-02-15 Impact factor: 3.857

6. Altered release of carnitine palmitoyltransferase activity by digitonin from liver mitochondria of rats in different physiological states.

Authors: V A Zammit; C G Corstorphine
Journal: Biochem J Date: 1985-09-01 Impact factor: 3.857

7. Starvation-induced changes of palmitate metabolism and insulin secretion in isolated rat islets stimulated by glucose.

Authors: J Tamarit-Rodríguez; E Vara; J Tamarit
Journal: Biochem J Date: 1984-07-15 Impact factor: 3.857

8. A cold-clamping technique for the rapid sampling of rat liver for studies on enzymes in separate cell fractions. Suitability for the study of enzymes regulated by reversible phosphorylation-dephosphorylation.

Authors: R A Easom; V A Zammit
Journal: Biochem J Date: 1984-06-15 Impact factor: 3.857

9. Carnitine palmitoyltransferase in liver and five extrahepatic tissues in the rat. Inhibition by DL-2-bromopalmitoyl-CoA and effect of hypothyroidism.

Authors: E D Saggerson; C A Carpenter
Journal: Biochem J Date: 1986-05-15 Impact factor: 3.857

10. Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation.

Authors: J C Reid; D R Husbands
Journal: Biochem J Date: 1985-01-01 Impact factor: 3.857