Literature DB >> 6497840

Conformational changes induced in bovine lens alpha-crystallin by carbamylation. Relevance to cataract.

H T Beswick, J J Harding.   

Abstract

Carbamylation of lens proteins may contribute to cataractogenesis in certain medical conditions where blood urea is elevated for prolonged periods. This paper reports on the effects of carbamylation on the physicochemical properties of one of the major lens structural proteins, alpha-crystallin. In particular it is shown that carbamylation alters the tertiary and secondary structure of the protein, leading to an increased reactivity of protein thiols, resulting in interchain disulphide bonding.

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Year:  1984        PMID： 6497840      PMCID： PMC1144283          DOI： 10.1042/bj2230221

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  23 in total

1.  Use of helical wheels to represent the structures of proteins and to identify segments with helical potential.

Authors:  M Schiffer; A B Edmundson
Journal:  Biophys J       Date:  1967-03       Impact factor: 4.033

2.  Kinetics of the carbamylation of the amino groups of sickle cell hemoglobin by cyanate.

Authors:  C K Lee; J M Manning
Journal:  J Biol Chem       Date:  1973-08-25       Impact factor: 5.157

3.  The amino-acid sequence of the alphaA2 chain of bovine alpha-crystallin.

Authors:  F J van der Ouderaa; W W de Jong; H Bloemendal
Journal:  Eur J Biochem       Date:  1973-11-01

4.  Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent.

Authors:  J Sedlak; R H Lindsay
Journal:  Anal Biochem       Date:  1968-10-24       Impact factor: 3.365

5.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

6.  Reactions of cyanate with functional groups of proteins. 3. Reactions with amino and carboxyl groups.

Authors:  G R Stark
Journal:  Biochemistry       Date:  1965-06       Impact factor: 3.162

7.  Slow rate of evolution of alpha A chain of alpha-crystallin.

Authors:  W W de Jong; F M van Amelsvoort; F J van der Ouderaa; H Bloemendal
Journal:  Nat New Biol       Date:  1973-12-19

8.  The optical rotatory dispersion and circular dichroism of calf lens alpha-crystallin.

Authors:  L K Li; A Spector
Journal:  J Biol Chem       Date:  1967-07-10       Impact factor: 5.157

9.  Isolation and some properties of bovine alpha-crystallin.

Authors:  A F van Dam; G ten Cate
Journal:  Biochim Biophys Acta       Date:  1966-05-26

10.  Conformational changes in human lens proteins in cataract.

Authors:  J J Harding
Journal:  Biochem J       Date:  1972-08       Impact factor: 3.857
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  19 in total

1.  αA-crystallin gene CpG islands hypermethylation in nuclear cataract after pars plana vitrectomy.

Authors:  Xiang-Jia Zhu; Ke-Ke Zhang; Peng Zhou; Chun-Hui Jiang; Yi Lu
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-02-10       Impact factor: 3.117

2.  Site of carbamoylation of bovine gamma-II-crystallin by potassium [14C]cyanate.

Authors:  S Martin; J J Harding
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

3.  Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis.

Authors:  Piotr Mydel; Zeneng Wang; Mikael Brisslert; Annelie Hellvard; Leif E Dahlberg; Stanley L Hazen; Maria Bokarewa
Journal:  J Immunol       Date:  2010-05-19       Impact factor: 5.422

4.  Isocyanic acid in the atmosphere and its possible link to smoke-related health effects.

Authors:  James M Roberts; Patrick R Veres; Anthony K Cochran; Carsten Warneke; Ian R Burling; Robert J Yokelson; Brian Lerner; Jessica B Gilman; William C Kuster; Ray Fall; Joost de Gouw
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-16       Impact factor: 11.205

5.  A case-control study of cataract in Oxfordshire: some risk factors.

Authors:  R van Heyningen; J J Harding
Journal:  Br J Ophthalmol       Date:  1988-11       Impact factor: 4.638

6.  Spatial analysis of human lens aquaporin-0 post-translational modifications by MALDI mass spectrometry tissue profiling.

Authors:  Danielle B Gutierrez; Donita Garland; Kevin L Schey
Journal:  Exp Eye Res       Date:  2011-10-25       Impact factor: 3.467

Review 7.  Cigarettes and cataract: cadmium or a lack of vitamin C?

Authors:  J J Harding
Journal:  Br J Ophthalmol       Date:  1995-03       Impact factor: 4.638

Review 8.  Protein carbamylation in end stage renal disease: is there a mortality effect?

Authors:  Sahir Kalim
Journal:  Curr Opin Nephrol Hypertens       Date:  2018-11       Impact factor: 2.894

9.  Conformational changes induced in lens alpha- and gamma-crystallins by modification with glucose 6-phosphate. Implications for cataract.

Authors:  H T Beswick; J J Harding
Journal:  Biochem J       Date:  1987-09-15       Impact factor: 3.857

10.  Methylation and carbamylation of human gamma-crystallins.

Authors:  Veniamin N Lapko; David L Smith; Jean B Smith
Journal:  Protein Sci       Date:  2003-08       Impact factor: 6.725
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