Literature DB >> 4646781

Conformational changes in human lens proteins in cataract.

J J Harding.   

Abstract

The reactivity of protein thiol groups in human lens and the susceptibility of the proteins to tryptic digestion were investigated. Both were found to be greater in some cataractous lenses, indicating that lens proteins have unfolded during cataractogenesis. Almost all the tyrosine in the proteins of the normal human lens reacts with tetranitromethane and is therefore probably on the outside of the major lens proteins.

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Year:  1972        PMID： 4646781      PMCID： PMC1174045          DOI： 10.1042/bj1290097

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

1.  The action of trypsin on polylysine.

Authors:  S G WALEY; J WATSON
Journal:  Biochem J       Date:  1953-09       Impact factor: 3.857

2.  The human lens. I. A comparison of cataracts extracted in Oxford (England) and Shikarpur (W. Pakistan).

Authors:  R Van Heyningen
Journal:  Exp Eye Res       Date:  1972-03       Impact factor: 3.467

3.  Hydrogen ion equilibria and the chemical modification of lysine and tyrosine residues in bovine carbonic anhydrase B.

Authors:  A Nilsson; S Lindskog
Journal:  Eur J Biochem       Date:  1967-10

4.  Isolation of nitrotyrosine-containing peptides by using an insoluble-antibody column.

Authors:  M Helman; D Givol
Journal:  Biochem J       Date:  1971-12       Impact factor: 3.857

5.  Immunochemical studies on albuminoid.

Authors:  W Manski; M Behrens; C Martinez
Journal:  Exp Eye Res       Date:  1968-01       Impact factor: 3.467

6.  Tetranitromethane. A reagent for the nitration of tyrosyl residues in proteins.

Authors:  M Sokolovsky; J F Riordan; B L Vallee
Journal:  Biochemistry       Date:  1966-11       Impact factor: 3.162

7.  Nature and origin of the insoluble protein of rat lens.

Authors:  J J Harding
Journal:  Exp Eye Res       Date:  1969-04       Impact factor: 3.467

8.  The glycoproteins and glycolipoproteins of the bovine lens and their relation to albuminoid.

Authors:  Z Dische
Journal:  Invest Ophthalmol       Date:  1965-10

9.  Human carbonic anhydrase B. Location of tyrosine residues that react with tetranitromethane.

Authors:  F Dorner
Journal:  J Biol Chem       Date:  1971-10-10       Impact factor: 5.157

10.  Chemical derivatives of subtilisin Carlsberg with increased proteolytic activity.

Authors:  J T Johansen; M Ottesen; I Svendsen
Journal:  Biochim Biophys Acta       Date:  1967-05-16
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  17 in total

1.  Site of carbamoylation of bovine gamma-II-crystallin by potassium [14C]cyanate.

Authors:  S Martin; J J Harding
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857

2.  Interaction of Estrogen Receptor Associated Protein (ERAP) 140 with ER beta decreases but its expression increases in aging mouse cerebral cortex.

Authors:  Vijay Paramanik; M K Thakur
Journal:  Cell Mol Neurobiol       Date:  2010-05-06       Impact factor: 5.046

3.  Loss of tryptophan associated with photo-polymerization and yellowing of proteins exposed to light over 300nm.

Authors:  K J Dilley
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

4.  Exposure of beta L-crystallin to oxidizing free radicals enhances its susceptibility to transglutaminase activity.

Authors:  M Seccia; O Brossa; E Gravela; T F Slater; K H Cheeseman
Journal:  Biochem J       Date:  1991-03-15       Impact factor: 3.857

5.  Conformational changes induced in bovine lens alpha-crystallin by carbamylation. Relevance to cataract.

Authors:  H T Beswick; J J Harding
Journal:  Biochem J       Date:  1984-10-01       Impact factor: 3.857

6.  Altered heat-lability of a fraction of glutathione reductase in aging human lens.

Authors:  J J Harding
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857

7.  Conformational changes induced in lens alpha- and gamma-crystallins by modification with glucose 6-phosphate. Implications for cataract.

Authors:  H T Beswick; J J Harding
Journal:  Biochem J       Date:  1987-09-15       Impact factor: 3.857

8.  RETRACTED: Peptide-induced formation of protein aggregates and amyloid fibrils in human and guinea pig αA-crystallins under physiological conditions of temperature and pH.

Authors:  Anbarasu Kumarasamy; Sivakumar Jeyarajan; Jonathan Cheon; Anthony Premceski; Eric Seidel; Victoria A Kimler; Frank J Giblin
Journal:  Exp Eye Res       Date:  2018-11-15       Impact factor: 3.467

9.  The identification of a reaction site of glutathione mixed-disulphide formation on gammaS-crystallin in human lens.

Authors:  Jane Craghill; Andrew D Cronshaw; John J Harding
Journal:  Biochem J       Date:  2004-05-01       Impact factor: 3.857

10.  Sample prep for proteomics of breast cancer: proteomics and gene ontology reveal dramatic differences in protein solubilization preferences of radioimmunoprecipitation assay and urea lysis buffers.

Authors:  Lambert C M Ngoka
Journal:  Proteome Sci       Date:  2008-10-24       Impact factor: 2.480
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