| Literature DB >> 649513 |
G Cassinelli, A Grein, P Masi, A Suarato, L Bernardi, F Arcamone, A Di Marco, A M Casazza, G Pratesi, C Soranzo.
Abstract
A mutant strain of Streptomyces peucetius produced an anthracycline antibiotic whose structure has been established to be 4-O-demethyl-13-dihydrodaunorubicin (4), by application of spectroscopic methods and chemical degradation. A new synthesis of 4-O-demethyl-daunorubicin (carminomycin I, 2) starting from daunomycinone, together with the comparison of the antitumor activity of the anthracycline glycosides 2 and 4 are also reported.Entities:
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Year: 1978 PMID： 649513 DOI： 10.7164/antibiotics.31.178
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649