Literature DB >> 6492164

Characterization of two crystal forms of neutrophil cationic protein NP2, a naturally occurring broad-spectrum antimicrobial agent from leukocytes.

E M Westbrook, R I Lehrer, M E Selsted.   

Abstract

A hexagonal crystal form (P6(3)22, a = b = 34.0 A, c = 113.5 A) and a monoclinic form (P2(1), a = 37.1 A, b = 32.2 A, c = 32.4 A, beta = 110 degrees) of neutrophil cationic protein NP2, isolated from rabbit leukocytes, have been characterized. The monoclinic form, containing two promoters (Mr = 3844) per asymmetric unit, diffracts to at least 1.8 A and is suitable for high-resolution structural studies.

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Year:  1984        PMID: 6492164     DOI: 10.1016/0022-2836(84)90252-3

Source DB:  PubMed          Journal:  J Mol Biol        ISSN: 0022-2836            Impact factor:   5.469


  4 in total

1.  Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin.

Authors:  M E Selsted; S S Harwig
Journal:  Infect Immun       Date:  1987-09       Impact factor: 3.441

2.  Defensins. Natural peptide antibiotics of human neutrophils.

Authors:  T Ganz; M E Selsted; D Szklarek; S S Harwig; K Daher; D F Bainton; R I Lehrer
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808

Review 3.  Mechanistic Landscape of Membrane-Permeabilizing Peptides.

Authors:  Shantanu Guha; Jenisha Ghimire; Eric Wu; William C Wimley
Journal:  Chem Rev       Date:  2019-01-09       Impact factor: 72.087

4.  Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.

Authors:  A J Ouellette; R M Greco; M James; D Frederick; J Naftilan; J T Fallon
Journal:  J Cell Biol       Date:  1989-05       Impact factor: 10.539

  4 in total

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