Literature DB >> 6491966

High-performance liquid chromatographic-ultraviolet determination of primaquine and its metabolites in human plasma and urine.

G W Parkhurst, M V Nora, R W Thomas, P E Carson.   

Abstract

A high-performance liquid chromatographic method was developed for the simultaneous determination of primaquine and its metabolites from plasma and urine samples obtained after oral administration of primaquine diphosphate. Following partial deproteinization with acetonitrile, samples were chromatographed by direct injection onto a cyano column with UV detection at 254 nm. Levels as low as 100 ng/mL per 20-microL injection were quantitated. Preliminary pharmacokinetic analysis is reported for two human volunteers after oral doses of 60 mg and 90 mg. Two apparent plasma metabolites and two possible urinary metabolites of primaquine are also reported.

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Year:  1984        PMID： 6491966     DOI： 10.1002/jps.2600730943

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  9 in total

1.  Increased bioavailability of primaquine using poly(ethylene oxide) matrix extended-release tablets administered to beagle dogs.

Authors:  C D Bertol; P R Oliveira; G Kuminek; G S Rauber; H K Stulzer; M A S Silva
Journal:  Ann Trop Med Parasitol       Date:  2011-10

2.  Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry.

Authors:  Warunee Hanpithakpong; Nicholas P J Day; Nicholas J White; Joel Tarning
Journal:  Malar J       Date:  2022-06-03       Impact factor: 3.469

3.  Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.

Authors:  S F Queener; M S Bartlett; J D Richardson; M M Durkin; M A Jay; J W Smith
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

4.  The pharmacokinetics of primaquine in calves after subcutaneous and intravenous administration.

Authors:  H Yoshimura; Y S Endoh; Y Ishihara; S Nakamura; Y Inoue
Journal:  Vet Res Commun       Date:  1993       Impact factor: 2.459

5.  Effect of aliphatic side-chain substituents on the antimalarial activity and on the metabolism of primaquine studied using mitochondria and microsome preparations.

Authors:  J K Baker; R H Yarber; N P Nanayakkara; J D McChesney; F Homo; I Landau
Journal:  Pharm Res       Date:  1990-01       Impact factor: 4.200

6.  Fungal metabolism of 4-methylprimaquine.

Authors:  A M Clark; J D McChesney; C D Hufford
Journal:  Pharm Res       Date:  1986-06       Impact factor: 4.200

7.  Excretion of metabolites in bile following the administration of primaquine to rats.

Authors:  J K Baker; J D McChesney; L A Walker
Journal:  Pharm Res       Date:  1985-09       Impact factor: 4.200

8.  Characterization of the urinary metabolites of primaquine in rats.

Authors:  J K Baker; J D McChesney; L F Jorge
Journal:  Pharm Res       Date:  1986-06       Impact factor: 4.200

9.  A pilot randomized controlled trial to compare the effectiveness of two 14-day primaquine regimens for the radical cure of vivax malaria in South India.

Authors:  Kavitha Saravu; Chaitanya Tellapragada; Shrivathsa Kulavalli; Wilbin Xavier; Shashikiran Umakanth; Gouthami Brahmarouphu; Navyasree Kola Srinivas; Jagadish Puralae Channabasavaiah; Anzil Bava; Abdul Vahab Saadi; Vasudev Guddattu; Kapaettu Satyamoorthy; Krishnamurthy Bhat
Journal:  Malar J       Date:  2018-09-03       Impact factor: 2.979
  9 in total

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