Literature DB >> 24272842

Excretion of metabolites in bile following the administration of primaquine to rats.

J K Baker1, J D McChesney, L A Walker.   

Abstract

Following the administration of primaquine diphosphate (20 mg/kg IP), six metabolites of primaquine were found in the bile of rats. Quantitative HPLC of the metabolites revealed that the sum of the six metabolites excreted in the bile represented a quantitative recovery of the dose of primaquine.

Entities:  

Year:  1985        PMID： 24272842     DOI： 10.1023/A:1016316928589

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  8 in total

1.  Collection of metabolites in bile and urine from the rat.

Authors:  G J Mulder; E Scholtens; D K Meijer
Journal:  Methods Enzymol       Date:  1981       Impact factor: 1.600

2.  High-performance liquid chromatographic--electrochemical assay method for primaquine in plasma and urine.

Authors:  M V Nora; G W Parkhurst; R W Thomas; P E Carson
Journal:  J Chromatogr       Date:  1984-05-11

3.  Excretion, distribution, and metabolism of primaquine in rats.

Authors:  A M Clark; J K Baker; J D McChesney
Journal:  J Pharm Sci       Date:  1984-04       Impact factor: 3.534

4.  Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite.

Authors:  G W Mihaly; S A Ward; G Edwards; M L Orme; A M Breckenridge
Journal:  Br J Clin Pharmacol       Date:  1984-04       Impact factor: 4.335

5.  Primaquine: metabolism by microorganisms and 13C nuclear magnetic resonance assignments.

Authors:  A M Clark; C D Huford; J D McChesney
Journal:  Antimicrob Agents Chemother       Date:  1981-02       Impact factor: 5.191

6.  High-performance liquid chromatographic analysis of the metabolism of primaquine and the identification of a new mammalian metabolite.

Authors:  J K Baker; J D McChesney; C D Hufford; A M Clark
Journal:  J Chromatogr       Date:  1982-06-11

7.  High-performance liquid chromatographic-ultraviolet determination of primaquine and its metabolites in human plasma and urine.

Authors:  G W Parkhurst; M V Nora; R W Thomas; P E Carson
Journal:  J Pharm Sci       Date:  1984-09       Impact factor: 3.534

8.  Metabolism and distribution of primaquine in monkeys.

Authors:  J K Baker; J A Bedford; A M Clark; J D McChesney
Journal:  Pharm Res       Date:  1984-03       Impact factor: 4.200
  8 in total

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