Literature DB >> 6491959

Anti-influenza A activity of some N-substituted bicyclo[3.2.1]octane-3-spiro-3'-pyrrolidine hydrochlorides: synthesis and structure.

E de la Cuesta, P Ballesteros, G G Trigo.   

Abstract

Some N-substituted bicyclo[3.2.1]octane-3-spiro-3'-pyrrolidine hydrochlorides (IX-XII) prepared from bicyclo[3.2.1]octan-3-one (I), were assayed in vitro against influenza A viruses. All materials showed activity similar to 1-adamantanamine hydrochloride. A 1H-NMR study revealed only one isomer at the spiro carbon atom.

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Year:  1984        PMID： 6491959     DOI： 10.1002/jps.2600730933

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  3 in total

1.  Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus.

Authors:  Christos Fytas; Antonios Kolocouris; George Fytas; Grigoris Zoidis; Charalampos Valmas; Christopher F Basler
Journal:  Bioorg Chem       Date:  2010-09-21       Impact factor: 5.275

Review 2.  The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Authors:  Lukas Wanka; Khalid Iqbal; Peter R Schreiner
Journal:  Chem Rev       Date:  2013-02-25       Impact factor: 60.622

3.  Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a.

Authors:  Joana Vitallé; Iñigo Terrén; Leire Gamboa-Urquijo; Ane Orrantia; Laura Tarancón-Díez; Miguel Genebat; Manuel Leal; Ezequiel Ruiz-Mateos; Francisco Borrego; Olatz Zenarruzabeitia
Journal:  Sci Rep       Date:  2020-04-08       Impact factor: 4.379
  3 in total

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