Literature DB >> 6489514

The competitive equilibrium between aluminium and ferric ions for the binding sites of transferrin.

M Cochran, J Coates, S Neoh.   

Abstract

Human transferrin is shown to bind 2 mol of aluminium per mol of protein using spectrophotometric titration. Competitive equilibrium between aluminium and ferric ions for transferrin binding sites is observed, and a value of 2.5 (+/- 0.4) X 10(15) M-1 is found for the apparent binding constant under physiological conditions.

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Year:  1984        PMID： 6489514     DOI： 10.1016/0014-5793(84)80926-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

Review 1.  Does aluminium have a pathogenic role in dialysis associated arthropathy?

Authors:  P Netter; M Kessler; A Gaucher; B Bannwarth
Journal:  Ann Rheum Dis       Date:  1990-08       Impact factor: 19.103

2.  The role of transferrin and citrate in cellular uptake of aluminium.

Authors:  S J McGregor; J H Brock; D Halls
Journal:  Biol Met       Date:  1991

3.  Distribution of aluminum in different brain regions and body organs of rat.

Authors:  D Julka; R K Vasishta; K D Gill
Journal:  Biol Trace Elem Res       Date:  1996-05       Impact factor: 3.738

4.  Aluminum access to the brain: a role for transferrin and its receptor.

Authors:  A J Roskams; J R Connor
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

5.  Aluminum accumulation in serum, liver and spleen of Fe-depleted and Fe-adequate rats.

Authors:  T S Brown; R Schwartz
Journal:  Biol Trace Elem Res       Date:  1992-07       Impact factor: 3.738

6.  Aluminum: a pH-dependent inhibitor of NADP-isocitrate dehydrogenase from porcine heart.

Authors:  M Yoshino; K Murakami
Journal:  Biometals       Date:  1992       Impact factor: 2.949

7.  An in vitro study on the binding of Al(III) to human serum transferrin with the isoelectric focusing technique.

Authors:  G de Jong; C C Ammerlaan; W L van Noort; H G van Eijk; G L van Landeghem; P C D'Haese; M E de Broe
Journal:  Biometals       Date:  1995-10       Impact factor: 2.949

8.  Aluminium transport in blood serum. Binding of aluminium by human transferrin in the presence of human albumin and citrate.

Authors:  S J Fatemi; F H Kadir; G R Moore
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

9.  Aluminum inhibits erythropoiesis in vitro.

Authors:  J Mladenovic
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808

Review 10.  Metabolism and possible health effects of aluminum.

Authors:  P O Ganrot
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031
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