Literature DB >> 6487474

The action of prazosin and propylene glycol on methoxamine-induced bronchoconstriction in asthmatic subjects.

J L Black, C Salome, K Yan, J Shaw.   

Abstract

The effect of 1 mg inhaled prazosin on bronchoconstriction induced by methoxamine was investigated in seven asthmatic subjects. Prazosin caused significant inhibition of the methoxamine-induced bronchoconstriction in six of the seven patients. These findings suggest that methoxamine produces bronchoconstriction in asthmatic subjects via stimulation of alpha-adrenoceptors. In previous studies propylene glycol has been used as a vehicle for delivery of prazosin. This substance was found to cause significant inhibition of methoxamine effects and to shift the dose response curve to histamine to the right in four of seven patients.

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Year:  1984        PMID： 6487474      PMCID： PMC1463636          DOI： 10.1111/j.1365-2125.1984.tb02475.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  13 in total

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Authors:  J Koch-Weser; R M Graham; W A Pettinger
Journal:  N Engl J Med       Date:  1979-02-01       Impact factor: 91.245

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Authors:  P M Lish; S I Robbins; K W Dungan
Journal:  J Pharmacol Exp Ther       Date:  1968-09       Impact factor: 4.030

3.  Influences of suggestion on airway reactivity in asthmatic subjects.

Authors:  T Luparello; H A Lyons; E R Bleecker; E R McFadden
Journal:  Psychosom Med       Date:  1968 Nov-Dec       Impact factor: 4.312

4.  Exercise-induced bronchospasm: effect of adrenergic or cholinergic blockade.

Authors:  R M Sly; E M Heimlich; R J Busser; L Strick
Journal:  J Allergy       Date:  1967-08

5.  Comparison between airways response to an alpha-adrenoceptor agonist and histamine in asthmatic and non-asthmatic subjects.

Authors:  J L Black; C M Salome; K Yan; J Shaw
Journal:  Br J Clin Pharmacol       Date:  1982-09       Impact factor: 4.335

6.  Bronchodilator activity of prazosin in patients with allergic rhinitis and asthma.

Authors:  G E Marlin; P J Thompson; H K Reddel; C M Chow; S Cheng
Journal:  Br J Clin Pharmacol       Date:  1982-03       Impact factor: 4.335

7.  Effect of alpha-receptor blocking drugs and disodium cromoglyate on histamine hypersensitivity in bronchial asthma.

Authors:  J W Kerr; M Govindaraj; K R Patel
Journal:  Br Med J       Date:  1970-04-18

8.  Inhaled prazosin in asthma.

Authors:  P J Barnes; P W Ind; C T Dollery
Journal:  Thorax       Date:  1981-05       Impact factor: 9.139

9.  Prazosin, an alpha 1-adrenoceptor antagonist, partially inhibits exercise-induced asthma.

Authors:  P J Barnes; N M Wilson; H Vickers
Journal:  J Allergy Clin Immunol       Date:  1981-12       Impact factor: 10.793

10.  Evaluation of ultrasonically nebulised solutions for provocation testing in patients with asthma.

Authors:  S D Anderson; R E Schoeffel; M Finney
Journal:  Thorax       Date:  1983-04       Impact factor: 9.139
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  4 in total

1.  Alpha 1-adrenoceptor function and autoradiographic distribution in human asthmatic lung.

Authors:  D Spina; P J Rigby; J W Paterson; R G Goldie
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

2.  Inhibition of methoxamine-induced bronchoconstriction by ipratropium bromide and disodium cromoglycate in asthmatic subjects.

Authors:  J Black; K Vincenc; C Salome
Journal:  Br J Clin Pharmacol       Date:  1985-07       Impact factor: 4.335

3.  Epinephrine evokes shortening of human airway smooth muscle cells following β2 adrenergic receptor desensitization.

Authors:  Brian T Deeney; Gaoyuan Cao; Sarah Orfanos; Jordan Lee; Mengyuan Kan; Blanca E Himes; Vishal Parikh; Cynthia J Koziol-White; Steven S An; Reynold A Panettieri
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2022-07-05       Impact factor: 6.011

Review 4.  Airway hyperresponsiveness: a story of mice and men and cytokines.

Authors:  Robert G Townley; Masahide Horiba
Journal:  Clin Rev Allergy Immunol       Date:  2003-02       Impact factor: 10.817
  4 in total

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