Literature DB >> 6487472

Lack of a pharmacokinetic interaction between nifedipine and the beta-adrenoceptor blockers metoprolol and atenolol.

M J Kendall, D B Jack, S J Laugher, J Lobo, S Rolf Smith.   

Abstract

Nifedipine, metoprolol and atenolol were administered orally to young, healthy volunteers. Each drug was given alone and nifedipine was also given with both beta-adrenoceptor blockers. Each drug was given for 3 days immediately before the study days. Plasma and urine drug concentrations were measured and the relevant pharmacokinetic parameters calculated. No pharmacokinetic interaction between nifedipine and the beta-adrenoceptor blockers was revealed.

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Year:  1984        PMID： 6487472      PMCID： PMC1463644          DOI： 10.1111/j.1365-2125.1984.tb02472.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  16 in total

1.  Pharmacokinetic interaction between propranolol and chlorpromazine in schizophrenic patients.

Authors:  M Peet; D N Middlemiss; R A Yates
Journal:  Lancet       Date:  1980-11-01       Impact factor: 79.321

2.  Lack of evidence for polymorphism in metoprolol metabolism.

Authors:  D B Jack; M Wilkins; C P Quarterman
Journal:  Br J Clin Pharmacol       Date:  1983-08       Impact factor: 4.335

Review 3.  Clinical pharmacokinetics of metoprolol.

Authors:  C G Regårdh; G Johnsson
Journal:  Clin Pharmacokinet       Date:  1980 Nov-Dec       Impact factor: 6.447

4.  Bioavailability of atenolol formulations.

Authors:  J Mcainsh; W T Simpson; B F Holmes; J Young; S H Ellis
Journal:  Biopharm Drug Dispos       Date:  1980 Oct-Dec       Impact factor: 1.627

5.  Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol.

Authors:  H R Ochs; G Carstens; D J Greenblatt
Journal:  N Engl J Med       Date:  1980-08-14       Impact factor: 91.245

6.  The effect of hydralazine on the pharmacokinetics of three different beta adrenoceptor antagonists: metoprolol, nadolol, and acebutolol.

Authors:  D B Jack; M J Kendall; S Dean; S J Laugher; R Zaman; M E Tenneson
Journal:  Biopharm Drug Dispos       Date:  1982 Jan-Mar       Impact factor: 1.627

7.  Effects of treatment with nifedipine and metoprolol in essential hypertension.

Authors:  R Eggertsen; L Hansson
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

8.  Nifedipine in the treatment of difficult hypertensives.

Authors:  S Dean; M J Kendall
Journal:  Eur J Clin Pharmacol       Date:  1983       Impact factor: 2.953

9.  Additive antianginal effect of verapamil in patients receiving propranolol.

Authors:  M Bassan; D Weiler-Ravell; O Shalev
Journal:  Br Med J (Clin Res Ed)       Date:  1982-04-10

10.  Nifedipine and propranolol: a beneficial drug interaction.

Authors:  H J Dargie; P G Lynch; D M Krikler; L Harris; S Krikler
Journal:  Am J Med       Date:  1981-10       Impact factor: 4.965
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  13 in total

1.  Nicardipine does not influence the pharmacokinetics and pharmacodynamics of atenolol.

Authors:  I Vercruysse; D F Schoors; G Musch; D L Massart; A G Dupont
Journal:  Br J Clin Pharmacol       Date:  1990-09       Impact factor: 4.335

2.  Kinetics and hemodynamic effects of intravenous nicardipine modified by previous propranolol oral treatment.

Authors:  P Rocha; M Guerret; D David; X Marchand; J C Kahn
Journal:  Cardiovasc Drugs Ther       Date:  1990-12       Impact factor: 3.727

Review 3.  Pharmacokinetic interactions with calcium channel antagonists (Part II).

Authors:  K D Schlanz; S A Myre; M B Bottorff
Journal:  Clin Pharmacokinet       Date:  1991-12       Impact factor: 6.447

Review 4.  Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.

Authors:  E M Sorkin; S P Clissold; R N Brogden
Journal:  Drugs       Date:  1985-09       Impact factor: 9.546

5.  The interactions between nisoldipine and two beta-adrenoceptor antagonists--atenolol and propranolol.

Authors:  H L Elliott; P A Meredith; C McNally; J L Reid
Journal:  Br J Clin Pharmacol       Date:  1991-09       Impact factor: 4.335

Review 6.  Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders.

Authors:  A N Wadworth; D Murdoch; R N Brogden
Journal:  Drugs       Date:  1991-09       Impact factor: 9.546

Review 7.  Clinical pharmacokinetics of calcium antagonists. An update.

Authors:  J G Kelly; K O'Malley
Journal:  Clin Pharmacokinet       Date:  1992-06       Impact factor: 6.447

8.  Plasma potassium changes in hypertensive patients undergoing oral surgery with local anesthetics containing epinephrine.

Authors:  J G Meechan
Journal:  Anesth Prog       Date:  1997

9.  Twelve hour (trough) plasma nifedipine concentrations during chronic treatment with nifedipine retard.

Authors:  M Beerahee; M R Wilkins; D B Jack; D G Beevers; M J Kendall
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953

10.  Pharmacokinetic interactions between felodipine and metoprolol.

Authors:  S R Smith; M R Wilkins; D B Jack; M J Kendall; S Laugher
Journal:  Eur J Clin Pharmacol       Date:  1987       Impact factor: 2.953
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