Literature DB >> 6487370

A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).

A Müller, E Cadenas, P Graf, H Sies.   

Abstract

a synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51), exhibits GSH peroxidase-like activity in vitro, in contrast to its sulfur analog, PZ 25. In addition, PZ 51 behaves as an antioxidant shown by a temporary protection of rat liver microsomes against ascorbate/ADP-Fe-induced lipid peroxidation, an effect also elicited by PZ 25 but to a smaller extent. This protection against lipid peroxidation is independent of GSH and of P-450 monooxygenase activity.

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Year:  1984        PMID： 6487370     DOI： 10.1016/0006-2952(84)90083-2

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  96 in total

1.  Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen.

Authors:  Jade B Aitken; Peter A Lay; T T Hong Duong; Roshanak Aran; Paul K Witting; Hugh H Harris; Barry Lai; Stefan Vogt; Gregory I Giles
Journal:  J Biol Inorg Chem       Date:  2012-02-11       Impact factor: 3.358

2.  Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation.

Authors:  Yongliang Liang; James R Roede; Sergey Dikalov; Nana Gletsu Miller; Samuel C Dudley; Arshed Quyyumi; Dean P Jones
Journal:  Clin Chim Acta       Date:  2012-06-08       Impact factor: 3.786

Review 3.  The pharmacology of ebselen.

Authors:  M J Parnham; S Leyck; E Graf; E J Dowling; D R Blake
Journal:  Agents Actions       Date:  1991-01

4.  Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.

Authors:  Susan M E Smith; Jaeki Min; Thota Ganesh; Becky Diebold; Tsukasa Kawahara; Yerun Zhu; James McCoy; Aiming Sun; James P Snyder; Haian Fu; Yuhong Du; Iestyn Lewis; J David Lambeth
Journal:  Chem Biol       Date:  2012-06-22

5.  Action of hypochlorous acid on the antioxidant protective enzymes superoxide dismutase, catalase and glutathione peroxidase.

Authors:  O I Aruoma; B Halliwell
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

6.  Evaluation of the neurotoxic/neuroprotective role of organoselenides using differentiated human neuroblastoma SH-SY5Y cell line challenged with 6-hydroxydopamine.

Authors:  Fernanda Martins Lopes; Giovana Ferreira Londero; Liana Marengo de Medeiros; Leonardo Lisbôa da Motta; Guilherme Antônio Behr; Valeska Aguiar de Oliveira; Mohammad Ibrahim; José Cláudio Fonseca Moreira; Lisiane de Oliveira Porciúncula; João Batista Teixeira da Rocha; Fábio Klamt
Journal:  Neurotox Res       Date:  2012-01-20       Impact factor: 3.911

7.  Selegiline and the Treatment of Parkinson's Disease: How patients can benefit from drug therapy.

Authors:  J S Richardson
Journal:  Can Fam Physician       Date:  1991-05       Impact factor: 3.275

8.  Comparative studies on dicholesteroyl diselenide and diphenyl diselenide as antioxidant agents and their effect on the activities of Na+/K+ ATPase and delta-aminolevulinic acid dehydratase in the rat brain.

Authors:  Ige J Kade; Marcio W Paixão; Oscar E D Rodrigues; Nilda B V Barbosa; Antonio L Braga; Daiana S Avila; Cristina W Nogueira; João B T Rocha
Journal:  Neurochem Res       Date:  2007-08-21       Impact factor: 3.996

9.  Glutathione peroxidase-1 inhibits transcription of regenerating islet-derived protein-2 in pancreatic islets.

Authors:  Jun-Won Yun; Zeping Zhao; Xi Yan; Marko Z Vatamaniuk; Xin Gen Lei
Journal:  Free Radic Biol Med       Date:  2019-01-28       Impact factor: 7.376

10.  A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity.

Authors:  Elizabeth R Sharlow; Todd A Lyda; Heidi C Dodson; Gabriela Mustata; Meredith T Morris; Stephanie S Leimgruber; Kuo-Hsiung Lee; Yoshiki Kashiwada; David Close; John S Lazo; James C Morris
Journal:  PLoS Negl Trop Dis       Date:  2010-04-13
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