Literature DB >> 2058468

The pharmacology of ebselen.

M J Parnham1, S Leyck, E Graf, E J Dowling, D R Blake.   

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Year:  1991        PMID: 2058468     DOI: 10.1007/bf01983300

Source DB:  PubMed          Journal:  Agents Actions        ISSN: 0065-4299


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  39 in total

1.  Neutrophil-derived oxidants mediate formyl-methionyl-leucyl-phenylalanine-induced increases in mucosal permeability in rats.

Authors:  C von Ritter; M B Grisham; M Hollwarth; W Inauen; D N Granger
Journal:  Gastroenterology       Date:  1989-09       Impact factor: 22.682

2.  Acute antiinflammatory and gastric effects of the seleno-organic compound ebselen.

Authors:  S Leyck; M J Parnham
Journal:  Agents Actions       Date:  1990-06

3.  Leukotrienes as mediators in frog virus 3-induced hepatitis in rats.

Authors:  W Hagmann; A M Steffan; A Kirn; D Keppler
Journal:  Hepatology       Date:  1987 Jul-Aug       Impact factor: 17.425

4.  Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats.

Authors:  Y Kurebayashi; Y Tabuchi; M Akasaki
Journal:  Arzneimittelforschung       Date:  1989-02

5.  Ebselen reduces the formation of LTB4 in human and porcine leukocytes by isomerisation to its 5S, 12R-6-trans-isomer.

Authors:  P Kuhl; H O Borbe; H Fischer; A Römer; H Safayhi
Journal:  Prostaglandins       Date:  1986-06

6.  Effects of the seleno-organic substance Ebselen in two different models of acute pancreatitis.

Authors:  C Niederau; K Ude; M Niederau; R Lüthen; G Strohmeyer; L D Ferrell; J H Grendell
Journal:  Pancreas       Date:  1991-05       Impact factor: 3.327

7.  Hypoxic-reperfusion injury in the inflamed human joint.

Authors:  D R Blake; P Merry; J Unsworth; B L Kidd; J M Outhwaite; R Ballard; C J Morris; L Gray; J Lunec
Journal:  Lancet       Date:  1989-02-11       Impact factor: 79.321

8.  Inhibition of superoxide anion radical production by ebselen (PZ51) and its sulfur analogue (PZ25) in guinea pig alveolar macrophages.

Authors:  R Leurs; H Timmerman; A Bast
Journal:  Biochem Int       Date:  1989-02

9.  A novel biologically active seleno-organic compound--II. Activity of PZ 51 in relation to glutathione peroxidase.

Authors:  A Wendel; M Fausel; H Safayhi; G Tiegs; R Otter
Journal:  Biochem Pharmacol       Date:  1984-10-15       Impact factor: 5.858

10.  Inhibitory effects of ebselen on lipid peroxidation in rat liver microsomes.

Authors:  M Hayashi; T F Slater
Journal:  Free Radic Res Commun       Date:  1986
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  8 in total

1.  Ebselen and congeners inhibit NADPH oxidase 2-dependent superoxide generation by interrupting the binding of regulatory subunits.

Authors:  Susan M E Smith; Jaeki Min; Thota Ganesh; Becky Diebold; Tsukasa Kawahara; Yerun Zhu; James McCoy; Aiming Sun; James P Snyder; Haian Fu; Yuhong Du; Iestyn Lewis; J David Lambeth
Journal:  Chem Biol       Date:  2012-06-22

2.  Progress does not just come in giant leaps: adapting techniques for the study of inflammation to novel applications.

Authors:  Michael J Parnham
Journal:  Inflamm Res       Date:  2016-09-28       Impact factor: 4.575

Review 3.  Prospects for the use of antioxidant therapies.

Authors:  S R Maxwell
Journal:  Drugs       Date:  1995-03       Impact factor: 9.546

Review 4.  Experimental and clinical evidence of antioxidant therapy in acute pancreatitis.

Authors:  Mukaddes Esrefoglu
Journal:  World J Gastroenterol       Date:  2012-10-21       Impact factor: 5.742

Review 5.  Toxicology and pharmacology of synthetic organoselenium compounds: an update.

Authors:  Cristina W Nogueira; Nilda V Barbosa; João B T Rocha
Journal:  Arch Toxicol       Date:  2021-04-01       Impact factor: 6.168

6.  Toll-like receptor 4-mediated nuclear factor kappa B activation is essential for sensing exogenous oxidants to propagate and maintain oxidative/nitrosative cellular stress.

Authors:  Rajendra Karki; Orisa J Igwe
Journal:  PLoS One       Date:  2013-09-18       Impact factor: 3.240

7.  Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.

Authors:  Paul D Hanavan; Chad R Borges; Benjamin A Katchman; Douglas O Faigel; Thai H Ho; Chen-Ting Ma; Eduard A Sergienko; Nathalie Meurice; Joachim L Petit; Douglas F Lake
Journal:  Oncotarget       Date:  2015-07-30

Review 8.  Drug antioxidant effects. A basis for drug selection?

Authors:  B Halliwell
Journal:  Drugs       Date:  1991-10       Impact factor: 9.546

  8 in total

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