Literature DB >> 6487307

In vitro biosynthesis of isoprene from mevalonate utilizing a rat liver cytosolic fraction.

E S Deneris, R A Stein, J F Mead.   

Abstract

The in vitro biosynthesis of isoprene from DL-mevalonate in the cytosolic fraction of rat liver is described. Evidence is provided suggesting a non-enzymatic formation of isoprene from isopentenyl pyrophosphate and/or dimethylallyl pyrophosphate. Furthermore, the data establish an alternate fate of the mevalonate carbon skeleton providing the first evidence that breath isoprene is linked to cholesterol biosynthesis.

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Year:  1984        PMID： 6487307     DOI： 10.1016/0006-291x(84)90284-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Effect of the influenza A (H1N1) live attenuated intranasal vaccine on nitric oxide (FE(NO)) and other volatiles in exhaled breath.

Authors:  A Mashir; K M Paschke; D van Duin; N K Shrestha; D Laskowski; M K Storer; B Yen-Lieberman; S M Gordon; M Aytekin; R A Dweik
Journal:  J Breath Res       Date:  2011-07-15       Impact factor: 3.262

Review 2.  Structural and Chemical Biology of Terpenoid Cyclases.

Authors:  David W Christianson
Journal:  Chem Rev       Date:  2017-08-25       Impact factor: 60.622

3.  Effect of regulating cholesterol biosynthesis on breath isoprene excretion in men.

Authors:  B G Stone; T J Besse; W C Duane; C D Evans; E G DeMaster
Journal:  Lipids       Date:  1993-08       Impact factor: 1.880

4.  Isoprene Exposure in the United States Based on Urinary IPM3: NHANES 2015-2016.

Authors:  Chloe Biren; Luyu Zhang; Deepak Bhandari; Benjamin C Blount; Víctor R De Jesús
Journal:  Environ Sci Technol       Date:  2020-01-31       Impact factor: 9.028

5.  Breath isoprene: muscle dystrophy patients support the concept of a pool of isoprene in the periphery of the human body.

Authors:  J King; P Mochalski; K Unterkofler; G Teschl; M Klieber; M Stein; A Amann; M Baumann
Journal:  Biochem Biophys Res Commun       Date:  2012-06-05       Impact factor: 3.575

6.  Short-Term Intra-Subject Variation in Exhaled Volatile Organic Compounds (VOCs) in COPD Patients and Healthy Controls and Its Effect on Disease Classification.

Authors:  Christopher Phillips; Neil Mac Parthaláin; Yasir Syed; Davide Deganello; Timothy Claypole; Keir Lewis
Journal:  Metabolites       Date:  2014-05-09

Review 7.  Breath analysis as a potential and non-invasive frontier in disease diagnosis: an overview.

Authors:  Jorge Pereira; Priscilla Porto-Figueira; Carina Cavaco; Khushman Taunk; Srikanth Rapole; Rahul Dhakne; Hampapathalu Nagarajaram; José S Câmara
Journal:  Metabolites       Date:  2015-01-09

8.  Isoprene in the Exhaled Breath is a Novel Biomarker for Advanced Fibrosis in Patients with Chronic Liver Disease: A Pilot Study.

Authors:  Naim Alkhouri; Tavankit Singh; Eyad Alsabbagh; John Guirguis; Tarek Chami; Ibrahim Hanouneh; David Grove; Rocio Lopez; Raed Dweik
Journal:  Clin Transl Gastroenterol       Date:  2015-09-17       Impact factor: 4.488

Review 9.  Significance of Exhaled Breath Test in Clinical Diagnosis: A Special Focus on the Detection of Diabetes Mellitus.

Authors:  Souvik Das; Saurabh Pal; Madhuchhanda Mitra
Journal:  J Med Biol Eng       Date:  2016-10-11       Impact factor: 1.553

10.  Sniffing Entrapped Humans with Sensor Arrays.

Authors:  Andreas T Güntner; Nicolay J Pineau; Paweł Mochalski; Helmut Wiesenhofer; Agapios Agapiou; Christopher A Mayhew; Sotiris E Pratsinis
Journal:  Anal Chem       Date:  2018-04-05       Impact factor: 6.986
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