Literature DB >> 6475956

Thymidine-kinase activity of cultured cells from individuals with inherited galactokinase deficiency.

R C Schoen, S H Cox, R P Wagner.   

Abstract

Cells of a person homozygous for galactokinase deficiency and of her heterozygous parents were found to be deficient in the enzyme thymidine kinase. The decrease in thymidine-kinase activity may be the result of a qualitative alteration in the enzyme molecule. This is reflected in the apparent alteration in the sensitivity of the enzyme to trifluorothymidine. It is suggested that this relationship between the galactokinase and thymidine kinase is not fortuitous but a reflection of their interdependence as found previously in the Chinese hamster.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6475956      PMCID： PMC1684481     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  28 in total

1.  Unstable, non-mutational expression of resistance to the thymidine analogue, trifluorothymidine in CHO cells.

Authors:  G M Adair; J H Carver
Journal:  Mutat Res       Date:  1979-04       Impact factor: 2.433

2.  A human-mouse somatic hybrid line selected for human deoxycytidine deaminase.

Authors:  T S Chan; C Long; H Green
Journal:  Somatic Cell Genet       Date:  1975-01

3.  Synteny of the genes for thymidine kinase and galactokinase in the mouse and their assignment to mouse chromosome 11.

Authors:  P McBreen; K G Orkwiszewski; C J Chern; W J Mellman; C M Croce
Journal:  Cytogenet Cell Genet       Date:  1977

4.  Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids.

Authors:  C A Kozak; F H Ruddle
Journal:  Somatic Cell Genet       Date:  1977-03

5.  Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer.

Authors:  O W McBride; J W Burch; F H Ruddle
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

6.  Ancient linkage groups and frozen accidents.

Authors:  S Ono
Journal:  Nature       Date:  1973-08-03       Impact factor: 49.962

7.  Inverse relationship between galactokinase activity and 2-deoxygalactose resistance in Chinese hamster ovary cells.

Authors:  C D Whitfield; B Buchsbaum; R Bostedor; E H Chu
Journal:  Somatic Cell Genet       Date:  1978-11

8.  Phenotype stabilisation and integration of transferred material in chromosome-mediated gene transfer.

Authors:  L A Klobutcher; F H Ruddle
Journal:  Nature       Date:  1979-08-23       Impact factor: 49.962

9.  Cotransfer of linked eukaryotic genes and efficient transfer of hypoxanthine phosphoribosyltransferase by DNA-mediated gene transfer.

Authors:  J L Peterson; O W McBride
Journal:  Proc Natl Acad Sci U S A       Date:  1980-03       Impact factor: 11.205

10.  Reversible inactivation of autosomal alleles in Chinese hamster cells.

Authors:  W E Bradley
Journal:  J Cell Physiol       Date:  1979-11       Impact factor: 6.384
View more
  4 in total

1.  Thymidine kinase activity in individuals with galactokinase deficiency.

Authors:  K Okajima; M Yazaki; Y Wada
Journal:  Am J Hum Genet       Date:  1987-09       Impact factor: 11.025

2.  A coordinate relationship between the GALK and the TK1 genes of the Chinese hamster.

Authors:  R P Wagner; S H Cox; R C Schoen
Journal:  Biochem Genet       Date:  1985-10       Impact factor: 1.890

3.  Oncogenes and linkage groups: conservation during mammalian chromosome evolution.

Authors:  R L Stallings; A C Munk; J L Longmire; J H Jett; M E Wilder; M J Siciliano; G M Adair; B D Crawford
Journal:  Chromosoma       Date:  1985       Impact factor: 4.316

4.  Normal expression of thymidine kinase and O6-methylguanine-DNA methyltransferase in cultured fibroblasts from individuals with hereditary galactokinase deficiency.

Authors:  C Stephenson; M Brivet; M Gautier; J Deschatrette; R Gitzelmann; P Karran
Journal:  Biochem Genet       Date:  1991-04       Impact factor: 1.890
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.