Literature DB >> 196814

Synteny of the genes for thymidine kinase and galactokinase in the mouse and their assignment to mouse chromosome 11.

P McBreen, K G Orkwiszewski, C J Chern, W J Mellman, C M Croce.   

Abstract

We have studied the expression of mouse galactokinase in human-mouse somatic cell hybrids segregating mouse chromosomes. Since concordant segregation of the expression of mouse galactokinase and the presence of mouse chromosome 11 were observed in the hybrid clones, we conclude that the gene for mouse galactokinase is located on mouse chromosome 11. We have also investigated the expression of mouse galactokinase in somatic cell hybrids between thymidine kinase-deficient Chinese hamster cells and mouse peritoneal macrophages. The results of this study indicate that the expression of mouse galactokinase and thymidine kinase segregates concordantly, and, therefore, we infer that the gene for mouse thymidine kinase is also located on mouse chromosome 11.

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Year:  1977        PMID： 196814     DOI： 10.1159/000130789

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  16 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

3.  Results and prospects of chromosomal gene transfer between cultured mammalian cells.

Authors:  K Willecke
Journal:  Theor Appl Genet       Date:  1978-05       Impact factor: 5.699

4.  A coordinate relationship between the GALK and the TK1 genes of the Chinese hamster.

Authors:  R P Wagner; S H Cox; R C Schoen
Journal:  Biochem Genet       Date:  1985-10       Impact factor: 1.890

5.  The genes for growth hormone and chorionic somatomammotropin are on the long arm of human chromosome 17 in region q21 to qter.

Authors:  D L George; J A Phillips; U Francke; P H Seeburg
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

6.  Cytogenetic evidence for hemizygosity at the thymidine kinase locus in P388 mouse lymphoma cells.

Authors:  A A Yasseen; P G McKenna
Journal:  Experientia       Date:  1983-05-15

7.  Chromosomal gene transfer of human cytosol thymidine kinase into mouse cells: integration or association of the transferred gene with a non-homologous mouse chromosome.

Authors:  K Willecke; R Mierau; A Krüger; R Lange
Journal:  Mol Gen Genet       Date:  1978-04-25

8.  Segregation of rat chromosomes in somatic cell hybrids between rat cells and HT 1080 human fibrosarcoma cells.

Authors:  G G D'Ancona; C M Croce
Journal:  Hum Genet       Date:  1979       Impact factor: 4.132

9.  Transcriptional and posttranscriptional mechanisms regulate murine thymidine kinase gene expression in serum-stimulated cells.

Authors:  H B Lieberman; P F Lin; D B Yeh; F H Ruddle
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

10.  Regional assignment of the genes for TK1, GALK, ALDC, and ESD on chromosome 8 in the American mink by chromosome-mediated gene transfer.

Authors:  A A Gradov; S D Pack; M A Sukoyan; N B Rubtsov; M N Bochkarev; O L Serov
Journal:  Mol Gen Genet       Date:  1985
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