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Literature DB >> 6469361

Identification of a high-affinity binder for estradiol and a low-affinity binder for testosterone in Coccidioides immitis.

Abstract

Coccidioides immitis cytosol contains a specific estrogen binder with kinetic characteristics (Kd = 2.1 X 10(-8) to 3.7 X 10(-8) M; n = 0.5 to 1.56 pmol/mg of protein) appropriate for interaction with levels of estrogen encountered during pregnancy. The Kd of a separate androgen binder (ca. 10(-7) M) is probably too low to allow interaction with physiological levels of testosterone.

Entities: Chemical

Mesh：

Substances：
Estrogens
Testosterone

Year: 1984 PMID： 6469361 PMCID： PMC263368 DOI： 10.1128/iai.45.3.784-786.1984

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

5 in total

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

Authors: M M Bradford
Journal: Anal Biochem Date: 1976-05-07 Impact factor: 3.365

2. Human sex hormones stimulate the growth and maturation of Coccidioides immitis.

Authors: D J Drutz; M Huppert; S H Sun; W L McGuire
Journal: Infect Immun Date: 1981-05 Impact factor: 3.441

3. Interrelations between plasma and tissue concentrations of 17 beta-oestradiol and progesterone during human pregnancy.

Authors: S Batra; L P Bengtsson; N O Sjöberg
Journal: Clin Endocrinol (Oxf) Date: 1979-12 Impact factor: 3.478

4. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.

Authors: J F Dunn; B C Nisula; D Rodbard
Journal: J Clin Endocrinol Metab Date: 1981-07 Impact factor: 5.958

5. Relationship of progesterone- and estradiol-binding proteins in Coccidioides immitis to coccidioidal dissemination in pregnancy.

Authors: B L Powell; D J Drutz; M Huppert; S H Sun
Journal: Infect Immun Date: 1983-05 Impact factor: 3.441

5 in total

6 in total

Identification of a high-affinity binder for estradiol and a low-affinity binder for testosterone in Coccidioides immitis.

1. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

2. Human sex hormones stimulate the growth and maturation of Coccidioides immitis.

3. Interrelations between plasma and tissue concentrations of 17 beta-oestradiol and progesterone during human pregnancy.

4. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma.

5. Relationship of progesterone- and estradiol-binding proteins in Coccidioides immitis to coccidioidal dissemination in pregnancy.

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Review 2. Virulence factors of medically important fungi.

Review 3. Coccidioidomycosis: host response and vaccine development.

4. Hormonal factors in vaginal candidiasis in rats.

5. Coccidioidomycosis in pregnancy: Case report and literature review of associated placental lesions.

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