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Literature DB >> 6469273

Effect of lactoferrin on the growth of a human colon adenocarcinoma cell line--comparison with transferrin.

M Amouric, J Marvaldi, J Pichon, F Bellot, C Figarella.

Abstract

Lactoferrin was examined for its effect on the growth of a human colon adenocarcinoma cell line (HT 29) in culture and its action was compared to that produced by transferrin and two different iron solutions (ferrous sulfate and ferric chloride). When transferrin was replaced by either iron solutions the cell grew in proportion to the quantity added and the maximal effect obtained was identical to that produced by transferrin alone. When transferrin was replaced by lactoferrin the cells were unable to proliferate for a long time. However, in the presence of low-concentration iron solutions, lactoferrin stimulated the cell growth, and the effect was more pronounced with the ferric chloride solution.

Entities: Chemical Disease Gene Species

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Year: 1984 PMID： 6469273 DOI： 10.1007/bf02639770

Source DB: PubMed Journal: In Vitro ISSN： 0073-5655

14 in total

1. Identification of transferrin receptors on the surface of human cultured cells.

Authors: T A Hamilton; H G Wada; H H Sussman
Journal: Proc Natl Acad Sci U S A Date: 1979-12 Impact factor: 11.205

2. Comparative circular dichroism studies of iron-free and iron-saturated forms of human serotransferrin and lactortransferrin.

Authors: J Mazurier; J P Aubert; M H Loucheux-Lefevre
Journal: FEBS Lett Date: 1976-07-15 Impact factor: 4.124

3. Growth and maintenance of HeLa cells in serum-free medium supplemented with hormones.

Authors: S E Hutchings; G H Sato
Journal: Proc Natl Acad Sci U S A Date: 1978-02 Impact factor: 11.205

4. Lactoferrin and transferrin: a comparative study.

Authors: P Aisen; A Leibman
Journal: Biochim Biophys Acta Date: 1972-02-29

5. Metal-combining properties of human lactoferrin. The possible involvement of tyrosyl residues in the binding sites. Spectrophotometric titration.

Authors: B Teuwissen; P L Masson; P Osinski; J F Heremans
Journal: Eur J Biochem Date: 1972-12-04

6. Replacement of serum by hormones permits growth of cells in a defined medium.

Authors: I Hayashi; G H Sato
Journal: Nature Date: 1976-01-15 Impact factor: 49.962

7. Anti-transferrin receptor monoclonal antibody and toxin-antibody conjugates affect growth of human tumour cells.

Authors: I S Trowbridge; D L Domingo
Journal: Nature Date: 1981-11-12 Impact factor: 49.962

8. Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro.

Authors: I S Trowbridge; F Lopez
Journal: Proc Natl Acad Sci U S A Date: 1982-02 Impact factor: 11.205

9. Comparative study of the iron-binding properties of transferrins. Differences in the involvement of histidine residues as revealed by carbethoxylation.

Authors: J Mazurier; D Leger; V Tordera; J Montreuil; G Spik
Journal: Eur J Biochem Date: 1981-10

10. Human leukocyte elastase, cathepsin G, and lactoferrin: family of neutrophil granule glycoproteins that bind to an alveolar macrophage receptor.

Authors: E J Campbell
Journal: Proc Natl Acad Sci U S A Date: 1982-11 Impact factor: 11.205

4 in total