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Literature DB >> 6468604

In vitro inactivation of the neurotoxic action of beta-bungarotoxin by the marine natural product, manoalide.

J C de Freitas, L A Blankemeier, R S Jacobs.

Abstract

The irreversible neurotoxic action of beta-bungarotoxin (beta-BuTx) can be prevented by preincubation of the toxin with manoalide, a non-steroidal anti-inflammatory agent. Manoalide was also found to inactivate purified phospholipase A2 and thus prevent hydrolysis of phosphatidylcholine. PLA2 is a component found in several neurotoxic venoms and is also a rate limiting enzyme important in phospholipid metabolism and prostaglandin synthesis in man.

Entities: Chemical Disease Gene Species

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Year: 1984 PMID： 6468604 DOI： 10.1007/bf01951998

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

12 in total

1. The role of phospholipase activity in the action of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake).

Authors: J Halpert; D Eaker; E Karlsson
Journal: FEBS Lett Date: 1976-01-01 Impact factor: 4.124

2. Isolation and characterization of presynaptically acting neurotoxins from the venom of Bungarus snakes.

Authors: T Abe; S Alemá; R Miledi
Journal: Eur J Biochem Date: 1977-10-17

3. Isolation and characterization of a toxic phospholipase A2 in the spitting cobra (Naja mossambica mossambica) venom.

Authors: N Martin-Moutot; H Rochat
Journal: Toxicon Date: 1979 Impact factor: 3.033

4. Selective inhibition by mepacrine of the release of "rabbit aorta contracting substance" evoked by the administration of bradykinin.

Authors: B B Vargaftig; N D Hai
Journal: J Pharm Pharmacol Date: 1972-02 Impact factor: 3.765

5. Stereochemical investigation of the active center of pepsin using a new inactivator.

Authors: B F Erlanger; S M Vratsanos; N Wassermann; A G Cooper
Journal: Biochem Biophys Res Commun Date: 1967-07-21 Impact factor: 3.575

6. The importance of phospholipase-A2 in prostaglandin biosynthesis.

Authors: R J Flower; G J Blackwell
Journal: Biochem Pharmacol Date: 1976-02-01 Impact factor: 5.858

7. Chemical modification of the histidine residue in phospholipase A2 from the Hemachatus haemachatus snake venom.

Authors: C C Yang; K King
Journal: Toxicon Date: 1980 Impact factor: 3.033

8. Chemical modification of the histidine residue in phospholipase A2 (Naja naja naja). A case of half-site reactivity.

Authors: M F Roberts; R A Deems; T C Mincey; E A Dennis
Journal: J Biol Chem Date: 1977-04-10 Impact factor: 5.157

9. The efficacy of anti-inflammatory agents with respect to extracellular phospholipase A2 activity.

Authors: P Vadas
Journal: Life Sci Date: 1982-01-11 Impact factor: 5.037

10. Characterization of phospholipase A activity of beta1-bungarotoxin from Bungarus multicinctus venom. II. Identification of the histidine residue of beta1-bungarotoxin modified by p-bromophenacyl bromide.

Authors: K Kondo; H Toda; K Narita
Journal: J Biochem Date: 1978-11 Impact factor: 3.387

6 in total

In vitro inactivation of the neurotoxic action of beta-bungarotoxin by the marine natural product, manoalide.

1. The role of phospholipase activity in the action of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake).

2. Isolation and characterization of presynaptically acting neurotoxins from the venom of Bungarus snakes.

3. Isolation and characterization of a toxic phospholipase A2 in the spitting cobra (Naja mossambica mossambica) venom.

4. Selective inhibition by mepacrine of the release of "rabbit aorta contracting substance" evoked by the administration of bradykinin.

5. Stereochemical investigation of the active center of pepsin using a new inactivator.

6. The importance of phospholipase-A2 in prostaglandin biosynthesis.

7. Chemical modification of the histidine residue in phospholipase A2 from the Hemachatus haemachatus snake venom.

8. Chemical modification of the histidine residue in phospholipase A2 (Naja naja naja). A case of half-site reactivity.

9. The efficacy of anti-inflammatory agents with respect to extracellular phospholipase A2 activity.

10. Characterization of phospholipase A activity of beta1-bungarotoxin from Bungarus multicinctus venom. II. Identification of the histidine residue of beta1-bungarotoxin modified by p-bromophenacyl bromide.

Review 1. Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance.

2. Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema.

3. Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellata.

Review 4. Anti-biofilm compounds derived from marine sponges.

5. Appraisal of antiophidic potential of marine sponges against Bothrops jararaca and Lachesis muta venom.

6. 24-O-ethylmanoalide, a manoalide-related sesterterpene from the marine sponge Luffariella cf. variabilis.