Literature DB >> 8846194

Effects of indole-3-acetic acid on croton oil- and arachidonic acid-induced mouse ear edema.

L H Jones1, D S Abdalla, J C Freitas.   

Abstract

The indole-3-acetic acid (IAA) is a plant growth hormone (auxin) being considered as a tryptophan metabolite in animals. The main purpose of this work was to verify IAA's topical anti-inflammatory action using croton oil- or arachidonic acid-induced mouse ear edema, in comparison to known anti-inflammatory agents. IAA antioxidant activity was also verified by measuring the inhibition of brain homogenate lipid peroxidation with the thiobarbituric acid reactive substances (TBARS) test. IAA inhibited the action of both croton oil-and arachidonic acid-induced edema in a dose-dependent manner (4.0 mumoles IAA inhibited 75.8% in croton oil and 82.5% in arachidonic acid induced ear edema). Both IAA (5.3 mM) and indomethacin (8.0 mM) inhibited TBARS formation. Data suggest that IAA exhibits antiinflammatory effect possibly by its anti-oxidant activity.

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Year:  1995        PMID： 8846194     DOI： 10.1007/bf01797863

Source DB:  PubMed          Journal:  Inflamm Res        ISSN： 1023-3830            Impact factor:   4.575


  52 in total

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Journal:  Agents Actions       Date:  1986-12

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Authors:  S N Young; G M Anderson; S Gauthier; W C Purdy
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Authors:  C L Ashendel; R K Boutwell
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7.  The inhibition of radical-initiated peroxidation of microsomal lipids by both alpha-tocopherol and beta-carotene.

Authors:  P Palozza; N I Krinsky
Journal:  Free Radic Biol Med       Date:  1991       Impact factor: 7.376

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Authors:  H Kondoh; Y Sato; H Kanoh
Journal:  J Invest Dermatol       Date:  1985-07       Impact factor: 8.551

9.  Indole-3-acetic acid in human cerebrospinal fluid: identification and quantification by mass fragmentography.

Authors:  L Bertilsson; L Palmér
Journal:  Science       Date:  1972-07-07       Impact factor: 47.728

10.  Tachyphylaxis in 12-0-tetradecanoylphorbol acetate- and arachidonic acid-induced ear edema.

Authors:  J M Young; B M Wagner; D A Spires
Journal:  J Invest Dermatol       Date:  1983-01       Impact factor: 8.551
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  6 in total

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3.  Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica.

Authors:  Marilena Antunes-Ricardo; Janet A Gutiérrez-Uribe; Carlos Martínez-Vitela; Sergio O Serna-Saldívar
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4.  The Protective Effect of Indole-3-Acetic Acid (IAA) on H2O2-Damaged Human Dental Pulp Stem Cells Is Mediated by the AKT Pathway and Involves Increased Expression of the Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) and Its Downstream Target Heme Oxygenase 1 (HO-1).

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5.  Indole-3-Acetic Acid Alters Intestinal Microbiota and Alleviates Ankylosing Spondylitis in Mice.

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Review 6.  Bacterial Natural Compounds with Anti-Inflammatory and Immunomodulatory Properties (Mini Review).

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