Literature DB >> 646820

A study of the role of the reactive thiol group of rabbit muscle creatine kinase with a chromophoric reporter group.

M A Keighren, N C Price.   

Abstract

Substrate- and ligand-induced conformational changes were studied in a series of thiol-modified derivatives of rabbit muscle creatine kinase that retained different amounts of enzymic activity. The results indicate that the 'reactive' thiol group of the enzyme is required for the conformational changes associated with formation of a 'transition-state analogue' complex.

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Year:  1978        PMID： 646820      PMCID： PMC1184157          DOI： 10.1042/bj1710269

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  Preparation and properties of S-cyano derivatives of creatine kinase.

Authors:  E der Terrossian; R Kassab
Journal:  Eur J Biochem       Date:  1976-11-15

2.  Simple alkanethiol groups for temporary blocking of sulfhydryl groups of enzymes.

Authors:  D J Smith; E T Maggio; G L Kenyon
Journal:  Biochemistry       Date:  1975-02-25       Impact factor: 3.162

3.  Spectrochemical and ligand-binding studies of an active mercurinitrophenol-labeled creatine kinase.

Authors:  M C Laue; F A Quiocho
Journal:  Biochemistry       Date:  1977-08-23       Impact factor: 3.162

4.  Non-identical behaviour of the subunits of rabbit muscule creatine kinase.

Authors:  N C Price; M G Hunter
Journal:  Biochim Biophys Acta       Date:  1976-09-14

5.  The interaction of 8-anilino-1-naphthalenesulfonate with creatine kinase. Evidence for cooperativitiy of nucleotide binding.

Authors:  A C McLaughlin
Journal:  J Biol Chem       Date:  1974-03-10       Impact factor: 5.157

6.  The role of the lysyl residue at the active site of creatine kinase. Nuclear Overhauser effect studies.

Authors:  T L James; M Cohn
Journal:  J Biol Chem       Date:  1974-04-25       Impact factor: 5.157

7.  Creatine kinase. Modification of the working enzyme.

Authors:  E J Milner-White; I D Kelly
Journal:  Biochem J       Date:  1976-07-01       Impact factor: 3.857

8.  Magnetic resonance studies of three forms of creatine kinase. Comparison of the properties of native, CH-S-blocked, and H2NCOCH-blocked enzymes.

Authors:  G D Markham; G H Reed
Journal:  J Biol Chem       Date:  1977-02-25       Impact factor: 5.157

9.  Properties of a CH3-blocked creatine kinase with altered catalytic activity. Kinetic consequences of the presence of the blocking group.

Authors:  E T Maggio; G L Kenyon
Journal:  J Biol Chem       Date:  1977-02-25       Impact factor: 5.157

10.  Substrate binding to an active creatine kinase with a thiol-bound mercurinitrophenol chromophoric probe.

Authors:  F E Quiocho; J W Thomson
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205
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  3 in total

1.  The reaction of rabbit muscle creatine kinase with diethyl pyrocarbonate.

Authors:  D E Clarke; N C Price
Journal:  Biochem J       Date:  1979-08-01       Impact factor: 3.857

2.  The reaction of rabbit muscle creatine kinase with some derivatives of iodoacetamide.

Authors:  N C Price
Journal:  Biochem J       Date:  1979-02-01       Impact factor: 3.857

3.  The effect of limited proteolysis on rabbit muscle creatine kinase.

Authors:  N C Price; S Murray; E J Milner-White
Journal:  Biochem J       Date:  1981-10-01       Impact factor: 3.857
  3 in total

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