Literature DB >> 6464656

The rat as an animal model for the study of senile idiopathic osteoporosis.

M R Simon.   

Abstract

Bone robustness of the major limb bones of 2-year-old and 3-year-old male Sprague-Dawley rats was determined and compared to that of 3-month-old male Sprague-Dawley rats. The results were compared to the published data on two different breeds of laboratory rats to ascertain if the laboratory rat is an appropriate animal model for the study of senile idiopathic osteoporosis in humans. The results show that the limb bone that becomes the most osteoporotic is the male Sprague-Dawley tibia. If one were selecting for the most appropriate breed of rat, it would be the Buffalo rat.

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Year:  1984        PMID： 6464656     DOI： 10.1159/000145893

Source DB:  PubMed          Journal:  Acta Anat (Basel)        ISSN： 0001-5180


  8 in total

1.  Chronic hyponatremia exacerbates multiple manifestations of senescence in male rats.

Authors:  Julia Barsony; Michaele B Manigrasso; Qin Xu; Helen Tam; Joseph G Verbalis
Journal:  Age (Dordr)       Date:  2012-01-05

2.  Effect of ovariectomy and prednisolone on bone mineral content in rats: evaluation by single photon absorptiometry and radiogrammetry.

Authors:  P Geusens; J Dequeker; J Nijs; E Bramm
Journal:  Calcif Tissue Int       Date:  1990-10       Impact factor: 4.333

3.  Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits.

Authors:  S Castañeda; R Largo; E Calvo; F Rodríguez-Salvanés; M E Marcos; M Díaz-Curiel; G Herrero-Beaumont
Journal:  Skeletal Radiol       Date:  2005-10-25       Impact factor: 2.199

4.  Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.

Authors:  M Matsushita; T Tsuboyama; R Kasai; H Okumura; T Yamamuro; K Higuchi; K Higuchi; A Kohno; T Yonezu; A Utani
Journal:  Am J Pathol       Date:  1986-11       Impact factor: 4.307

5.  Correlation between densitometric and hystomorphometric values in isolated vertebrae of Sprague-Dawley rats.

Authors:  I Campodarve; A Diez; J Puig; S Serrano; M L Mariñoso; M D Arnau; J Cucurull; J Ibáñez; X Nogués; J Aubia
Journal:  Calcif Tissue Int       Date:  1993-06       Impact factor: 4.333

6.  Characterization of a new experimental model of osteoporosis in rabbits.

Authors:  Santos Castañeda; Emilio Calvo; Raquel Largo; Rocío González-González; Concepción de la Piedra; Manuel Díaz-Curiel; Gabriel Herrero-Beaumont
Journal:  J Bone Miner Metab       Date:  2008-01-10       Impact factor: 2.626

7.  Ability of different techniques of measuring bone mass to determine vertebral bone loss in aging female rats.

Authors:  M Safadi; D Shapira; I Leichter; A Reznick; M Silbermann
Journal:  Calcif Tissue Int       Date:  1988-06       Impact factor: 4.333

8.  Comparative bone analysis via inflammation-mediated osteopenia (IMO) in the rat.

Authors:  F Bauss; H W Minne; H Sterz; U Weng; H Wesch; R Ziegler
Journal:  Calcif Tissue Int       Date:  1985-09       Impact factor: 4.333
  8 in total

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