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Literature DB >> 646444

Clinical applications of serum theophylline measurement by high pressure liquid chromatography.

S A McKenzie, A T Edmunds, E Baillie, J H Meek.

Abstract

Serum theophylline concentration was measured in children both during treatment of status asthmaticus with intravenous aminophylline, and as outpatients while they were taking oral theophylline compounds for long-term management of asthma. The clinical value of the measurements was assessed. Measurement using high-pressure liquid chromatography is simple and requires only a small volume of blood. Knowledge of serum theophylline concentration facilitates careful control of dosage of both intravenous aminophylline during treatment of status asthmaticus, and of oral theophylline in outpatients. It is useful in the evaluation of symptoms which may be due to toxic side effects of treatment. It also makes possible an assessment of patient compliance with prescribed treatment among those whose symptoms have not improved.

Entities: Chemical Disease Species

Mesh：

Substances：
Theophylline

Year: 1978 PMID： 646444 PMCID： PMC1544863 DOI： 10.1136/adc.53.4.322

Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791

10 in total

1. Study of theophylline plasma levels after oral administration of new theophylline compounds.

Authors: M TURNER-WARWICK
Journal: Br Med J Date: 1957-07-13

2. An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues.

Authors: J A SCHACK; S H WAXLER
Journal: J Pharmacol Exp Ther Date: 1949-11 Impact factor: 4.030

3. Pharmacokinetics of theophylline in children with asthma.

Authors: E F Ellis; R Koysooko; G Levy
Journal: Pediatrics Date: 1976-10 Impact factor: 7.124

4. Evaluation of oral bronchodilator therapy in asthmatic children. Bronchodilators in asthmatic children.

Authors: M M Weinberger; E A Bronsky
Journal: J Pediatr Date: 1974-03 Impact factor: 4.406

5. A re-evaluation of parenteral aminophylline.

Authors: D P Nicholson; T W Chick
Journal: Am Rev Respir Dis Date: 1973-08

6. Rational intravenous doses of theophylline.

Authors: P A Mitenko; R I Ogilvie
Journal: N Engl J Med Date: 1973-09-20 Impact factor: 91.245

7. Theophylline-induced seizures in adults. Correlation with serum concentrations.

Authors: C W Zwillich; F D Sutton; T A Neff; W M Cohn; R A Matthay; M M Weinberger
Journal: Ann Intern Med Date: 1975-06 Impact factor: 25.391

8. Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels.

Authors: R D Eney; E O Goldstein
Journal: Pediatrics Date: 1976-04 Impact factor: 7.124

9. Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate.

Authors: S A McKenzie; E Baillie; S Godfrey
Journal: Arch Dis Child Date: 1978-02 Impact factor: 3.791

10. Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study.

Authors: G Hambleton; M Weinberger; J Taylor; M Cavanaugh; E Ginchansky; S Godfrey; M Tooley; T Bell; S Greenberg
Journal: Lancet Date: 1977-02-19 Impact factor: 79.321

10 in total

11 in total

5. Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations.

Authors: S McKenzie; E Baillie
Journal: Arch Dis Child Date: 1978-12 Impact factor: 3.791

Clinical applications of serum theophylline measurement by high pressure liquid chromatography.

1. Study of theophylline plasma levels after oral administration of new theophylline compounds.

2. An ultraviolet spectrophotometric method for the determination of theophylline and theobromine in blood and tissues.

3. Pharmacokinetics of theophylline in children with asthma.

4. Evaluation of oral bronchodilator therapy in asthmatic children. Bronchodilators in asthmatic children.

5. A re-evaluation of parenteral aminophylline.

6. Rational intravenous doses of theophylline.

7. Theophylline-induced seizures in adults. Correlation with serum concentrations.

8. Compliance of chronic asthmatics with oral administration of theophylline as measured by serum and salivary levels.

9. Effect of practical timing of dosage on theophylline blood levels in asthmatic children treated with choline theophyllinate.

10. Comparison of cromoglycate (cromolyn) and theophylline in controlling symptoms of chronic asthma. A collaborative study.

Review 1. Drug interferences with plasma assays in therapeutic drug monitoring.

2. Controlled trial of slow-release aminophylline in childhood asthma: are short-term trials valid?

Review 3. Drug level monitoring in paediatric practice.

4. Sustained release oral aminophylline in patients with airflow obstruction.

5. Serum theophylline levels in asthmatic children after oral administration of two slow-release theophylline preparations.

6. A once daily theophylline preparation in prevention of nocturnal symptoms in childhood asthma.

7. Lack of influence of an intensive antacid regimen on theophylline bioavailability.

8. Status asthmaticus in children: a one-year study.

9. Dosage schedule for intravenous aminophylline in apnoea of prematurity, based on pharmacokinetic studies.

10. Cardiovascular response during severe acute asthma and its treatment in children.