Literature DB >> 6461445

Requirement for OKT8+ suppressor cell proliferation for suppression by human newborn T cells.

A R Hayward, D Merrill.   

Abstract

The percentage of cells bearing the suppressor phenotype OKT8+increases in PWM-stimulated cultures of human newborn lymphocytes. Prevention of this increase either by adding 50 microM deoxyguanosine to the cultures of by pretreating the newborn cells with OKT8 and complement reduced the suppressor activity of newborn T cells. These results suggest that newborn T cells are not intrinsically suppressive, but that they become so in vitro after stimulation by PWM.

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Year:  1981        PMID： 6461445      PMCID： PMC1537415     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  20 in total

1.  Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine.

Authors:  D A Carson; J Kaye; J E Seegmiller
Journal:  J Immunol       Date:  1978-11       Impact factor: 5.422

2.  Induction of plasma cell differentiation of human fetal lymphocytes: evidence for functional immaturity of T and B cells.

Authors:  A R Hayward; A R Lawton
Journal:  J Immunol       Date:  1977-10       Impact factor: 5.422

3.  Suppression of B lymphocyte differentiation by newborn T lymphocytes with an Fc receptor for IgM.

Authors:  A R Hayward; P M Lydyard
Journal:  Clin Exp Immunol       Date:  1978-12       Impact factor: 4.330

4.  Helper and suppressor-inducer activity of human T cells and their cloned progeny maintained in long-term culture.

Authors:  J T Kurnick; A R Hayward; P Altevogt
Journal:  J Immunol       Date:  1981-04       Impact factor: 5.422

5.  Separation of functional subsets of human T cells by a monoclonal antibody.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

6.  A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  J Immunol       Date:  1980-03       Impact factor: 5.422

7.  Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression.

Authors:  E L Reinherz; P C Kung; J M Pesando; J Ritz; G Goldstein; S F Schlossman
Journal:  J Exp Med       Date:  1979-12-01       Impact factor: 14.307

8.  Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function.

Authors:  E W Gelfand; J J Lee; H M Dosch
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

9.  Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

Authors:  D A Carson; J Kaye; S Matsumoto; J E Seegmiller; L Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-05       Impact factor: 11.205

10.  Interaction of maternal and neonatal cells in mixed-lymphocyte cultures.

Authors:  S D Lawler; E O Ukaejiofo; B R Reeves
Journal:  Lancet       Date:  1975-12-13       Impact factor: 79.321
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  6 in total

1.  Immunological aspects of progeria (Hutchinson-Gilford syndrome) in a 15-month-old child.

Authors:  M Harjacek; D Batinić; V Sarnavka; B Uzarević; D Mardesić; M Marusić
Journal:  Eur J Pediatr       Date:  1990-11       Impact factor: 3.183

2.  Cellular defenses against Toxoplasma gondii in newborns.

Authors:  C B Wilson; J E Haas
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808

3.  Pre-B cell suppression by thymoma patient lymphocytes.

Authors:  A R Hayward; P Paolucci; A D Webster; P Kohler
Journal:  Clin Exp Immunol       Date:  1982-05       Impact factor: 4.330

4.  Increased incidence of transient homogeneous immunoglobulins in irradiated and reconstituted C57BL/KaLwRij mice treated with 2'-deoxyguanosine.

Authors:  T W van den Akker; A P Gillen; H Bril; R Benner; J Radl
Journal:  Clin Exp Immunol       Date:  1983-11       Impact factor: 4.330

5.  Immunoregulation of immunoglobulin production in normal infants and children.

Authors:  K T Nouri-Aria; A Lobo-Yeo; D Vergani; G Mieli-Vergani; A P Mowat; A L Eddleston
Journal:  Clin Exp Immunol       Date:  1985-03       Impact factor: 4.330

6.  Identification of lymphocyte subsets in the newborn using a variety of monoclonal antibodies.

Authors:  R M Thomas; D C Linch
Journal:  Arch Dis Child       Date:  1983-01       Impact factor: 3.791
  6 in total

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