Literature DB >> 313056

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines.

D A Carson, J Kaye, S Matsumoto, J E Seegmiller, L Thompson.   

Abstract

Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.

Entities:  

Mesh：

Substances：

Year:  1979        PMID： 313056      PMCID： PMC383615          DOI： 10.1073/pnas.76.5.2430

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  27 in total

1.  Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).

Authors:  D A Carson; J Kaye; J E Seegmiller
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

2.  Differential sensitivity of human leukemic T cell lines and B cell lines to growth inhibition by deoxyadenosine.

Authors:  D A Carson; J Kaye; J E Seegmiller
Journal:  J Immunol       Date:  1978-11       Impact factor: 5.422

3.  Adenosine deaminase activity during the growth cycle of T and B lymphoid cell lines.

Authors:  G L Tritsch; J Minowada
Journal:  Immunol Commun       Date:  1977

4.  Specificity of adenosine deaminase inhibitors.

Authors:  J F Henderson; L Brox; G Zombor; D Hunting; C A Lomax
Journal:  Biochem Pharmacol       Date:  1977-11-01       Impact factor: 5.858

5.  Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease.

Authors:  J Donofrio; M S Coleman; J J Hutton; A Daoud; B Lampkin; J Dyminski
Journal:  J Clin Invest       Date:  1978-10       Impact factor: 14.808

6.  L-asparagine requirements of human T-lymphocytes and B-lymphocytes in culture.

Authors:  T Ohnuma; J F Holland; H Arkin; J Minowada
Journal:  J Natl Cancer Inst       Date:  1977-10       Impact factor: 13.506

7.  Predictive tests for cancer chemotherapy.

Authors:  E Frei; H Lazarus
Journal:  N Engl J Med       Date:  1978-06-15       Impact factor: 91.245

8.  Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency.

Authors:  A Cohen; L J Gudas; A J Ammann; G E Staal; D W Martin
Journal:  J Clin Invest       Date:  1978-05       Impact factor: 14.808

9.  Purinogenic immunodeficiency diseases: selective toxicity of deoxyribonucleosides for T cells.

Authors:  B S Mitchell; E Mejias; P E Daddona; W N Kelley
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

10.  Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

Authors:  A Cohen; R Hirschhorn; S D Horowitz; A Rubinstein; S H Polmar; R Hong; D W Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205
View more
  49 in total

1.  Lymphocytic adenosine deaminase activity in typhoid fevers.

Authors:  S N Khosla; D Kumar; V Singh
Journal:  Postgrad Med J       Date:  1992-04       Impact factor: 2.401

Review 2.  Heberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.

Authors:  J E Seegmiller
Journal:  Ann Rheum Dis       Date:  1980-04       Impact factor: 19.103

3.  Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse.

Authors:  F F Snyder; J P Jenuth; E R Mably; R K Mangat
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

4.  Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells.

Authors:  Kumudha Balakrishnan; Jan A Burger; Maite P Quiroga; Marina Henneberg; Mary L Ayres; William G Wierda; Varsha Gandhi
Journal:  Blood       Date:  2010-05-04       Impact factor: 22.113

5.  B cells as well as T cells form deoxynucleotides from either deoxyadenosine or deoxyguanosine.

Authors:  A Goday; H A Simmonds; G S Morris; L D Fairbanks
Journal:  Clin Exp Immunol       Date:  1984-04       Impact factor: 4.330

6.  Distribution of 5'-nucleotidase in human lymphoid tissues.

Authors:  N L Edwards; E W Gelfand; L Burk; H M Dosch; I H Fox
Journal:  Proc Natl Acad Sci U S A       Date:  1979-07       Impact factor: 11.205

7.  Ecto-adenosine triphosphatase deficiency in cultured human T and null leukemic lymphocytes. A biochemical basis for thymidine sensitivity.

Authors:  R M Fox; S K Piddington; E H Tripp; M H Tattersall
Journal:  J Clin Invest       Date:  1981-08       Impact factor: 14.808

8.  Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.

Authors:  M S Hershfield; N M Kredich
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

9.  Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.

Authors:  D A Carson; D B Wasson; J Kaye; B Ullman; D W Martin; R K Robins; J A Montgomery
Journal:  Proc Natl Acad Sci U S A       Date:  1980-11       Impact factor: 11.205

10.  Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death.

Authors:  Vilasack Thammavongsa; Dominique M Missiakas; Olaf Schneewind
Journal:  Science       Date:  2013-11-15       Impact factor: 47.728
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.