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Literature DB >> 6461443

The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases.

Abstract

Monoclonal antibodies are now available to evaluate human T cell subsets by direct counting using indirect immunofluorescence analysis. The critical use of these antibodies has already permitted the delineation of the T cell imbalances present in a number of immunologically mediated diseases such as autoimmune haemolytic anaemia, chronic active hepatitis, myasthenia gravis, glomerulonephritides, multiple sclerosis, leprosy, or immunodeficiency syndromes. The potential diagnostic and therapeutic application of this new methodology are emphasized.

Entities: Disease Species

Mesh：

Substances：

Year: 1981 PMID： 6461443 PMCID： PMC1537411

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

27 in total

1. A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells.

Authors: E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal: J Immunol Date: 1979-09 Impact factor: 5.422

2. F(ab')2 reagents are not required if goat, rather than rabbit, antibodies are used to detect human surface immunoglobulin.

Authors: E L Alexander; S K Sanders
Journal: J Immunol Date: 1977-09 Impact factor: 5.422

Review 3. Evaluation of T-cells and thymic serum factors in man using the rosette technique.

Authors: J F Bach
Journal: Transplant Rev Date: 1973

4. An Lyt differentiated thymocyte subpopulation detected by flow microfluorometry.

Authors: B J Mathieson; S O Sharrow; P S Campbell; R Asofsky
Journal: Nature Date: 1979-02-08 Impact factor: 49.962

5. Studies on T cell subsets and functions in leprosy.

Authors: M A Bach; L Chatenoud; D Wallach; F Phan Dinh Tuy; F Cottenot
Journal: Clin Exp Immunol Date: 1981-06 Impact factor: 4.330

6. Aberrations of suppressor T cells in human graft-versus-host disease.

Authors: E L Reinherz; R Parkman; J Rappeport; F S Rosen; S F Schlossman
Journal: N Engl J Med Date: 1979-05-10 Impact factor: 91.245

7. Selective depression of the xenogeneic cell-mediated lympholysis in systemic lupus erythematosus.

Authors: B Charpentier; C Carnaud; J F Bach
Journal: J Clin Invest Date: 1979-08 Impact factor: 14.808

8. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody.

Authors: A J McMichael; J R Pilch; G Galfré; D Y Mason; J W Fabre; C Milstein
Journal: Eur J Immunol Date: 1979-03 Impact factor: 5.532

9. Two functionally distinct subpopulations of human T cells that collaborate in the generation of cytotoxic cells responsible for cell-mediated lympholysis.

Authors: R L Evans; H Lazarus; A C Penta; S F Schlossman
Journal: J Immunol Date: 1978-04 Impact factor: 5.422

10. Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.

Authors: D D Eardley; J Hugenberger; L McVay-Boudreau; F W Shen; R K Gershon; H Cantor
Journal: J Exp Med Date: 1978-04-01 Impact factor: 14.307

37 in total

10. Lymphocyte function in human bone marrow. II. Characterization of an interleukin 2-sensitive T precursor-cell population.

Authors: H M Dosch; C J Ledgley; D White; P Lam; G B Mills
Journal: J Clin Immunol Date: 1985-09 Impact factor: 8.317

The use of monoclonal anti-T cell antibodies to study T cell imbalances in human diseases.

1. A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells.

2. F(ab')2 reagents are not required if goat, rather than rabbit, antibodies are used to detect human surface immunoglobulin.

Review 3. Evaluation of T-cells and thymic serum factors in man using the rosette technique.

4. An Lyt differentiated thymocyte subpopulation detected by flow microfluorometry.

5. Studies on T cell subsets and functions in leprosy.

6. Aberrations of suppressor T cells in human graft-versus-host disease.

7. Selective depression of the xenogeneic cell-mediated lympholysis in systemic lupus erythematosus.

8. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody.

9. Two functionally distinct subpopulations of human T cells that collaborate in the generation of cytotoxic cells responsible for cell-mediated lympholysis.

10. Immunoregulatory circuits among T-cell sets. I. T-helper cells induce other T-cell sets to exert feedback inhibition.

Review 1. Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis.

2. Immature T lymphocytes after injury characterized by morphology and phenotypic markers.

3. Lymphocyte subpopulations in patients with hydroxocobalamin responsive megaloblastic anaemia.

4. Peripheral blood lymphocyte subpopulations in patients with primary proliferative and secondary polycythaemia.

5. [Effect of PIND-AVI on various ratios of helper and suppressor T lymphocytes].

6. Evaluation of T cell subsets in Behçet's syndrome using anti-T cell monoclonal antibodies.

7. The clinical use of monoclonal anti-T-cell antibodies.

Review 8. Immunoregulatory T cells in multiple sclerosis: markers and functions.

9. Monoclonal antibody-defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid.

10. Lymphocyte function in human bone marrow. II. Characterization of an interleukin 2-sensitive T precursor-cell population.