| Literature DB >> 6459115 |
A J McMichael, N A Rust, J R Pilch, R Sochynsky, J Morton, D Y Mason, C Ruan, G Tobelem, J Caen.
Abstract
A monoclonal hybridoma antibody specific for platelet glycoprotein I complex is described. The nature od the antigen was determined by demonstration that it was chymotrypsin sensitive and gave a peak at 150 000 daltons on SDS-PAGE after immunoprecipitation. The expression of the antigen is restricted to platelets and megakaryocytes with at least 1.6 x 10(4) molecules of antigen per platelet. The antibody failed to bind to platelets from patients with Bernard Soulier syndrome, where there is known to be a deficiency of glycoprotein Ib/Is expression. Binding to platelets from patients with Glanzmann's thrombasthenia was normal.Entities:
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Year: 1981 PMID： 6459115 DOI： 10.1111/j.1365-2141.1981.tb07258.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998