Literature DB >> 6458707

Effects of nicotinamide on NAD and poly(ADP-ribose) metabolism in DNA-damaged human lymphocytes.

J L Sims, S J Berger, N A Berger.   

Abstract

The effect of nicotinamide on unscheduled DNA synthesis was studied in resting human lymphocytes. In cells treated with UV irradiation or with MNNG, nicotinamide caused a two-fold stimulation of unscheduled DNA synthesis and retarded the rate of NAD+ lowering caused by these treatments. Nicotinamide also reduced the burst of poly(ADP-ribose) synthesis caused by MNNG treatment. Thus under conditions that it enhances unscheduled DNA synthesis, nicotinamide causes marked effects on the metabolism of NAD+ and poly(ADP-ribose). The effect of nicotinamide on unscheduled DNA synthesis was shown to be independent of protein or polyamine synthesis.

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Year:  1981        PMID： 6458707     DOI： 10.1002/jsscb.1981.380160308

Source DB:  PubMed          Journal:  J Supramol Struct Cell Biochem        ISSN： 0275-3723


  13 in total

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