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Literature DB >> 6455043

Reduction of zearalenone to zearalenol in female rat liver by 3 alpha-hydroxysteroid dehydrogenase.

Abstract

The distribution of the zearalenone reducing activity was investigated in liver fractions obtained by differential centrifugation of liver homogenate from adult female Sprague Dawley rats. The zearalenone reducing enzyme was identified as 3 alpha-hydroxysteroid dehydrogenase. At least two multiple forms occur of the enzyme with different subcellular locations and pH-optima. The activity was localized in the microsomes with NADH as coenzyme and in both microsomes and cytosol with NADPH.

Entities: Chemical Gene Species

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Year: 1981 PMID： 6455043 DOI： 10.1111/j.1600-0773.1981.tb01602.x

Source DB: PubMed Journal: Acta Pharmacol Toxicol (Copenh) ISSN： 0001-6683

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Cited

12 in total

1. Interaction of zearalenone with bovine serum albumin as determined by fluorescence quenching.

Authors: Liang Ma; Chris M Maragos; Yuhao Zhang
Journal: Mycotoxin Res Date: 2017-11-13 Impact factor: 3.833

2. Hydroxysteroid dehydrogenases in bovine and porcine granulosa cells convert zearalenone into its hydroxylated metabolites alpha-zearalenol and beta-zearalenol.

Authors: H Malekinejad; B Colenbrander; J Fink-Gremmels
Journal: Vet Res Commun Date: 2006-05 Impact factor: 2.459

3. Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis.

Authors: Intidhar Ben Salem; Manel Boussabbeh; Alexandre Prola; Arnaud Guilbert; Hassen Bacha; Christophe Lemaire; Salwa Abid-Essefi
Journal: Environ Sci Pollut Res Int Date: 2016-04-28 Impact factor: 4.223

4. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria.

Authors: K H Kiessling; H Pettersson; K Sandholm; M Olsen
Journal: Appl Environ Microbiol Date: 1984-05 Impact factor: 4.792

5. Inducing effect of testosterone on the hepatic reduction of zearalenone in the female prepubertal rat.

Authors: M Olsen
Journal: Mycotoxin Res Date: 1985-09 Impact factor: 3.833

6. Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring.

Authors: Xin Gao; Lvhui Sun; Niya Zhang; Chong Li; Jiacai Zhang; Zhuohui Xiao; Desheng Qi
Journal: Toxins (Basel) Date: 2017-01-05 Impact factor: 4.546

Reduction of zearalenone to zearalenol in female rat liver by 3 alpha-hydroxysteroid dehydrogenase.

1. Interaction of zearalenone with bovine serum albumin as determined by fluorescence quenching.

2. Hydroxysteroid dehydrogenases in bovine and porcine granulosa cells convert zearalenone into its hydroxylated metabolites alpha-zearalenol and beta-zearalenol.

3. Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis.

4. Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria.

5. Inducing effect of testosterone on the hepatic reduction of zearalenone in the female prepubertal rat.

6. Gestational Zearalenone Exposure Causes Reproductive and Developmental Toxicity in Pregnant Rats and Female Offspring.

7. Alleviation of mycotoxin biodegradation agent on zearalenone and deoxynivalenol toxicosis in immature gilts.

8. Analysis of the miRNA Expression Profiles in the Zearalenone-Exposed TM3 Leydig Cell Line.

9. Effects of Dietary Exposure to Zearalenone (ZEN) on Carp (Cyprinus carpio L.).

10. Glucuronidation as a metabolic barrier against zearalenone in rat everted intestine.