Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Inducing effect of testosterone on the hepatic reduction of zearalenone in the female prepubertal rat.

Literature DB >> 23605788

Inducing effect of testosterone on the hepatic reduction of zearalenone in the female prepubertal rat.

Abstract

The prepubertal responsiveness of 3α-hydroxysteroid dehydrogenase and zeara-lenone-reducing activity to either a large subcutaneous dose of testosterone or dietary zearalenone was investigated in female rats. Testosterone induced both the activity of the 3α-hydroxysteroid dehydrogenase, with androsterone as substrate, and zearalenone reduction to α- and (β-zearalenol. Zearalenone had no effect on the activity of 3α-hydroxysteroid dehydrogenase, but had a slight inducing effect on the zearalenone reduction to β-zearalenol. Both testosterone and zearalenone had a growth-promoting effect on uterus.

Entities: Chemical Gene Species

Year: 1985 PMID： 23605788 DOI： 10.1007/BF03192003

Source DB: PubMed Journal: Mycotoxin Res ISSN： 0178-7888 Impact factor: 3.833

Keyword Cloud
References

16 in total

1. Metabolism of zearalenone in rat liver.

Authors: K H Kiessling; H Pettersson
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1978-10

2. Mechanism of Fusarium mycotoxin action in mammary gland.

Authors: P A Boyd; J L Wittliff
Journal: J Toxicol Environ Health Date: 1978-01

3. [Sexually differentiated and sexually undifferentiated 3alpha- and 3beta-hydroxysteroid dehydrogenase activities and their intracellular localization in rat liver].

Authors: H G Hoff; H Schriefers
Journal: Hoppe Seylers Z Physiol Chem Date: 1973-05

4. An improved method for the determination of cytoplasmic 3 alpha- and 17 beta- and microsomal 3 alpha-hydroxysteroid dehydrogenase activities in rat liver.

Authors: E R Lax; E Kreuzfelder; H Schriefers
Journal: Hoppe Seylers Z Physiol Chem Date: 1979-07

5. Androgen-uterine interactions: an assessment of androgen interaction with the testosterone- and estrogen-receptor systems and stimulation of uterine growth and progesterone-receptor synthesis.

Authors: W N Schmidt; B S Katzenellenbogen
Journal: Mol Cell Endocrinol Date: 1979-08 Impact factor: 4.102

6. Quantitative liquid chromatographic method using fluorescence detection for determining zearalenone and its metabolites in blood plasma and urine.

Authors: M E Olsen; H I Pettersson; K A Sandholm; K H Kiessling
Journal: J Assoc Off Anal Chem Date: 1985 Jul-Aug

Inducing effect of testosterone on the hepatic reduction of zearalenone in the female prepubertal rat.

1. Metabolism of zearalenone in rat liver.

2. Mechanism of Fusarium mycotoxin action in mammary gland.

3. [Sexually differentiated and sexually undifferentiated 3alpha- and 3beta-hydroxysteroid dehydrogenase activities and their intracellular localization in rat liver].

4. An improved method for the determination of cytoplasmic 3 alpha- and 17 beta- and microsomal 3 alpha-hydroxysteroid dehydrogenase activities in rat liver.

5. Androgen-uterine interactions: an assessment of androgen interaction with the testosterone- and estrogen-receptor systems and stimulation of uterine growth and progesterone-receptor synthesis.

6. Quantitative liquid chromatographic method using fluorescence detection for determining zearalenone and its metabolites in blood plasma and urine.

7. Zearalenone reductase from rat liver.

8. Species differences in zearalenone-reductase activity.

9. Transformations of zearalenone and alpha-zearalanol by homogenates of human prostate glands.

10. Reduction of zearalenone to zearalenol in female rat liver by 3 alpha-hydroxysteroid dehydrogenase.