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Literature DB >> 6452524

Origin of the additional chromosome in Down's syndrome: a study of 20 families.

Abstract

In 20 families with a Down's syndrome child, heteromorphism of chromosome 21 was sought in the parents and proband. Information on the meiotic division and the parent of origin was given in 16 families, the majority of errors being maternal in origin, predominantly at meiosis I, though the paternal contribution is also appreciable. Probabilities of parental and meiotic division origin are calculated.

Entities: Disease Species

Mesh：

Year: 1980 PMID： 6452524 PMCID： PMC1048599 DOI： 10.1136/jmg.17.5.363

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

9 in total

1. Origin of trisomies in human spontaneous abortions.

Authors: T Hassold; A Matsuyama
Journal: Hum Genet Date: 1979-02-15 Impact factor: 4.132

2. Parental origin of the extra chromosome in Down's syndrome.

Authors: R E Magenis; K M Overton; J Chamberlin; T Brady; E Lovrien
Journal: Hum Genet Date: 1977-06-10 Impact factor: 4.132

3. Cytogenetic darkroom magic: now you see them, now you don't.

Authors: K M Overton; R E Magenis; T Brady; J Chamberlin; M Parks
Journal: Am J Hum Genet Date: 1976-07 Impact factor: 11.025

4. Origin of extra chromosome in trisomy 21.

Authors: J A Robinson
Journal: Lancet Date: 1973-01-20 Impact factor: 79.321

5. Distinction between extra G-like chromosomes by quinacrine mustard fluorescence analysis.

Authors: T Caspersson; M Hultén; J Lindsten; L Zech
Journal: Exp Cell Res Date: 1970-11 Impact factor: 3.905

6. The Christchurch chromosome (Gp-). Mongolism, erythroleukemia and an inherited Gp- chromosome (Christchurch).

Authors: R C Juberg; B Jones
Journal: N Engl J Med Date: 1970-02-05 Impact factor: 91.245

7. [21 p-maternal in duplicate in a case of trisomy 21].

Authors: J de Grouchy
Journal: Ann Genet Date: 1970-03

8. Origin of human trisomics and polyploids.

Authors: P A Jacobs; N E Morton
Journal: Hum Hered Date: 1977 Impact factor: 0.444

9. The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability.

Authors: T Caspersson; G Lomakka; L Zech
Journal: Hereditas Date: 1972 Impact factor: 3.271

9 in total

8 in total

Origin of the additional chromosome in Down's syndrome: a study of 20 families.

1. Origin of trisomies in human spontaneous abortions.

2. Parental origin of the extra chromosome in Down's syndrome.

3. Cytogenetic darkroom magic: now you see them, now you don't.

4. Origin of extra chromosome in trisomy 21.

5. Distinction between extra G-like chromosomes by quinacrine mustard fluorescence analysis.

6. The Christchurch chromosome (Gp-). Mongolism, erythroleukemia and an inherited Gp- chromosome (Christchurch).

7. [21 p-maternal in duplicate in a case of trisomy 21].

8. Origin of human trisomics and polyploids.

9. The 24 fluorescence patterns of the human metaphase chromosomes - distinguishing characters and variability.

1. Parental age and the origin of trisomy 21. A study of 302 families.

2. An analysis for paternal-age effect in Ohio's Down syndrome births, 1970-1980.

3. Trisomy 21: origin of non-disjunction.

4. Satellite association in Down's syndrome.

5. The effect of age on the frequency of sperm chromosomal abnormalities in normal men.

6. Seasonality of pre-ovulatory non-disjunction and the aetiology of Down syndrome. A European collaborative study.

7. Maternal-age effect in aneuploidy: does altered embryonic selection play a role?

8. Family building in parents with Down's syndrome children.