Literature DB >> 6452165

On the mechanism of action of anesthetics. Direct inhibition of mitochondrial F1-ATPase by n-butanol and tetracaine.

G Vanderkooi, J Shaw, C Storms, R Vennerstrom, D Chignell.   

Abstract

The concentrations of n-butanol and tetracaine required for 50% inhibition of the ATPase activity of F1 particles isolated from bovine heart mitochondria were 160 mM and 1.1 mM, respectively. The results are offered as evidence that the physiological effects of these anesthetics may be due to direct interaction with membrane proteins rather than with the lipids.

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Year:  1981        PMID： 6452165     DOI： 10.1016/0005-2728(81)90019-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

Review 1.  ATP synthase and the actions of inhibitors utilized to study its roles in human health, disease, and other scientific areas.

Authors:  Sangjin Hong; Peter L Pedersen
Journal:  Microbiol Mol Biol Rev       Date:  2008-12       Impact factor: 11.056

2.  Local anesthetics: a new class of partial inhibitors of mitochondrial ATPase.

Authors:  A B Adade; D Chignell; G Vanderkooi
Journal:  J Bioenerg Biomembr       Date:  1984-12       Impact factor: 2.945

3.  Different concentrations of local anaesthetics have different modes of action on human lymphocytes.

Authors:  G V Ramus; L Cesano; A Barbalonga
Journal:  Agents Actions       Date:  1983-06

4.  Cytochrome c oxidase inhibition by anesthetics: thermodynamic analysis.

Authors:  G Vanderkooi; B Chazotte
Journal:  Proc Natl Acad Sci U S A       Date:  1982-06       Impact factor: 11.205

5.  Inhibition by trifluoperazine of ATP synthesis and hydrolysis by particulate and soluble mitochondrial F1: competition with H2PO4-.

Authors:  J J García; M Tuena de Gómez-Puyou; A Gómez-Puyou
Journal:  J Bioenerg Biomembr       Date:  1995-02       Impact factor: 2.945
  5 in total

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