Literature DB >> 6242242

Local anesthetics: a new class of partial inhibitors of mitochondrial ATPase.

A B Adade, D Chignell, G Vanderkooi.   

Abstract

The following characteristics are reported for mitochondrial ATPase prepared by the chloroform extraction method: (1) The pH optimum for enzyme activity is at 8.0. (2) The neutral anesthetic benzocaine inhibits the enzyme at all pH values. (3) Reciprocal plots of 1/v versus 1/[ATP] show that inhibition by lidocaine, tetracaine, dibucaine, and chlorpromazine is noncompetitive; slope and intercept replots are hyperbolic, showing that the inhibition is partial rather than complete.

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Year:  1984        PMID： 6242242     DOI： 10.1007/bf00743231

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  20 in total

1.  A simple and rapid method for the preparation of adenosine triphosphatase from submitochondrial particles.

Authors:  R B Beechey; S A Hubbard; P E Linnett; A D Mitchell; E A Munn
Journal:  Biochem J       Date:  1975-06       Impact factor: 3.857

2.  KINETIC STUDIES OF THE ACTIVATION OF MITOCHONDRIAL ADENOSINE TRIPHOSPHATASE BY MG++.

Authors:  F ULRICH
Journal:  J Biol Chem       Date:  1964-10       Impact factor: 5.157

3.  Partial resolution of the enzymes catalyzing oxidative phosphorylation. II. Participation of a soluble adenosine tolphosphatase in oxidative phosphorylation.

Authors:  H S PENEFSKY; M E PULLMAN; A DATTA; E RACKER
Journal:  J Biol Chem       Date:  1960-11       Impact factor: 5.157

4.  Effects of general anesthetics on lipid protein interactions and ATPase activity in mitochondria.

Authors:  G Lenaz; G Curatola; L Mazzanti; G Parenti-Castelli; E Bertoli
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

5.  Preparation of the soluble ATPase from mitochondria, chloroplasts, and bacteria by the chloroform technique.

Authors:  P E Linnett; A D Mitchell; M D Partis; R B Beechey
Journal:  Methods Enzymol       Date:  1979       Impact factor: 1.600

6.  Aurovertin, a fluorescent probe of conformational change in beef heart mitochondrial adenosine triphosphatase.

Authors:  T Chang; H S Penefsky
Journal:  J Biol Chem       Date:  1973-04-25       Impact factor: 5.157

7.  Selective disaggregation of the H+-translocating ATPase. Isolation of two discrete complexes of the rutamycin-insensitive ATPase differing in mitochondrial membrane-binding properties.

Authors:  R J Fisher; A M Liang; G C Sundstrom
Journal:  J Biol Chem       Date:  1981-01-25       Impact factor: 5.157

8.  Temperature dependence of anesthetic effects on succinate oxidase activity in uncoupled submitochondrial particles.

Authors:  G Vanderkooi; B Chazotte; R Biethman
Journal:  FEBS Lett       Date:  1978-06-01       Impact factor: 4.124

9.  Influence of aurovertin on mitochondrial ATPase activity.

Authors:  R E Ebel; H A Lardy
Journal:  J Biol Chem       Date:  1975-07-10       Impact factor: 5.157

10.  Quinacrine mustard inactivates the bovine heart mitochondrial F1-ATPase with the modification of the beta subunit.

Authors:  P K Laikind; W S Allison
Journal:  J Biol Chem       Date:  1983-10-10       Impact factor: 5.157
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  4 in total

1.  Unisite hydrolysis of [gamma 32 P]ATP by soluble mitochondrial F1-ATPase and its release by excess ADP and ATP. Effect of trifluoperazine.

Authors:  J J García; A Gómez-Puyou; M T de Gómez-Puyou
Journal:  J Bioenerg Biomembr       Date:  1997-02       Impact factor: 2.945

2.  Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity.

Authors:  Juliana Damasceno Oliveira; Lígia Nunes de Morais Ribeiro; Gustavo Henrique Rodrigues da Silva; Bruna Renata Casadei; Verônica Muniz Couto; Elizabeth Ferreira Martinez; Eneida de Paula
Journal:  Pharm Res       Date:  2018-10-10       Impact factor: 4.200

3.  The antioxidant N-acetyl cysteine suppresses lidocaine-induced intracellular reactive oxygen species production and cell death in neuronal SH-SY5Y cells.

Authors:  Akihisa Okamoto; Masahiro Tanaka; Chisato Sumi; Kanako Oku; Munenori Kusunoki; Kenichiro Nishi; Yoshiyuki Matsuo; Keizo Takenaga; Koh Shingu; Kiichi Hirota
Journal:  BMC Anesthesiol       Date:  2016-10-24       Impact factor: 2.217

4.  Encapsulation of ropivacaine in a combined (donor-acceptor, ionic-gradient) liposomal system promotes extended anesthesia time.

Authors:  Camila Morais Gonçalves da Silva; Michelle Franz-Montan; Cíntia Elisabeth Gomez Limia; Lígia Nunes de Morais Ribeiro; Mário Antônio Braga; Viviane Aparecida Guilherme; Camila Batista da Silva; Bruna Renata Casadei; Cíntia Maria Saia Cereda; Eneida de Paula
Journal:  PLoS One       Date:  2017-10-05       Impact factor: 3.240
  4 in total

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