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Literature DB >> 6451218

Huntington's-chorea fibroblasts. Cellular protein glycosylation.

Abstract

Five cell cultures of Huntington's-chorea fibroblasts exhibit greater than normal protein and lipid glycosylation when labelled with [U-14C]glucosamine. Oligosaccharide--polypeptide chains from all molecular-weight ranges are labelled differentially on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. This difference in protein glycosylation is not accompanied by any apparent difference in general cellular protein synthesis or by a differential rate of glucosamine uptake or decreased degradation of [14C]glycosylated macromolecules. Additionally [U-14C]glucosamine exclusively labels hexosamines and sialic acid of cellular macromolecules.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1980 PMID： 6451218 PMCID： PMC1162151 DOI： 10.1042/bj1900711

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

19 in total

1. The sialic acids. XVIII. Subcellular distribution of seven glycosyltransferases in embryonic chicken brain.

Authors: H Den; B Kaufman; E J McGuire; S Roseman
Journal: J Biol Chem Date: 1975-01-25 Impact factor: 5.157

Review 2. Neurobiology and pharmacology of Huntington's disease.

Authors: S J Enna
Journal: Life Sci Date: 1977-01-15 Impact factor: 5.037

3. Huntington's chorea. Deficiency of gamma-aminobutyric acid in brain.

Authors: T L Perry; S Hansen; M Kloster
Journal: N Engl J Med Date: 1973-02-15 Impact factor: 91.245

4. Transport and metabolism of glucosamine by cultured Novikoff rat hepatoma cells and effects on nucleotide pools.

Authors: P G Plagemann; J Erbe
Journal: Cancer Res Date: 1973-03 Impact factor: 12.701

5. The defect in Hurler's and Hunter's syndromes: faulty degradation of mucopolysaccharide.

Authors: J C Fratantoni; C W Hall; E F Neufeld
Journal: Proc Natl Acad Sci U S A Date: 1968-06 Impact factor: 11.205

6. The effect of D-glucosamine on the adenine and uridine nucleotides of sarcoma 180 ascites tumor cells.

Authors: J G Bekesi; R J Winzler
Journal: J Biol Chem Date: 1969-10-25 Impact factor: 5.157

7. Properties of some glycosyltransferases in embryonic chicken brain.

Authors: H Den; B Kaufman; S Roseman
Journal: J Biol Chem Date: 1970-12-25 Impact factor: 5.157

8. Cellular membranes: the biosynthesis of glycoprotein and glycolipid in hela cell membranes.

Authors: H B Bosmann; A Hagopian; E H Eylar
Journal: Arch Biochem Biophys Date: 1969-03 Impact factor: 4.013

9. Glycoprotein synthesis in a temperature-sensitive Chinese hamster cell cycle mutant.

Authors: A Tenner; J Zieg; I E Scheffler
Journal: J Cell Physiol Date: 1977-02 Impact factor: 6.384

10. Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia.

Authors: E D Bird; L L Iversen
Journal: Brain Date: 1974-09 Impact factor: 13.501

5 in total

1. Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity.

Authors: Richard G Sánchez; R Ryley Parrish; Megan Rich; William M Webb; Roxanne M Lockhart; Kazuhito Nakao; Lara Ianov; Susan C Buckingham; Devin R Broadwater; Alistair Jenkins; Nihal C de Lanerolle; Mark Cunningham; Tore Eid; Kristen Riley; Farah D Lubin
Journal: Neurobiol Dis Date: 2019-01-06 Impact factor: 5.996