Literature DB >> 6450261

Phenotypic characterization of human cytolytic T lymphocytes in mixed lymphocyte culture.

A Moretta, M C Mingari, B F Haynes, R P Sekaly, L Moretta, A S Fauci.   

Abstract

Mixed lymphocyte reaction (MLR)-activated T cells were analyzed according to the expression of various cell surface markers by the specific cytotoxic T lymphocytes (CTL) generated in the MLR. CTL were found exclusively in a population of MLR-activated T cells that lacked detectable Fc gamma R but that expressed a surface antigen recognized by the 4F2 monoclonal antibody. In contrast, CTL were found in both the Ia-positive and Ia-negative cells after MLR activation. Thus, the specific CTL generated in the allogeneic MLR can be identified and isolated by virtue of the expression of a particular cell surface marker.

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Year:  1981        PMID： 6450261      PMCID： PMC2186048          DOI： 10.1084/jem.153.1.213

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

1.  Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells.

Authors:  M Ferrarini; L Moretta; R Abrile; M L Durante
Journal:  Eur J Immunol       Date:  1975-01       Impact factor: 5.532

2.  Loss of Fc receptors for IgG from human T lymphocytes exposed to IgG immune complexes.

Authors:  L Moretta; M C Mingari; C A Romanzi
Journal:  Nature       Date:  1978-04-13       Impact factor: 49.962

3.  Insoluble immune complexes suppress mitogen-induced proliferation of human T lymphocytes bearing Fc gamma receptors.

Authors:  C Samarut; G Cordier; J P Revillard
Journal:  Cell Immunol       Date:  1979-01       Impact factor: 4.868

4.  Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens.

Authors:  G S Eisenbarth; B F Haynes; J A Schroer; A S Fauci
Journal:  J Immunol       Date:  1980-03       Impact factor: 5.422

5.  Activation of human B lymphocytes. II. Cellular interactions in the PFC response of human tonsillar and peripheral blood B lymphocytes to polyclonal activation by pokeweed mitogen.

Authors:  A S Fauci; K R Pratt; G Whalen
Journal:  J Immunol       Date:  1976-12       Impact factor: 5.422

6.  Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness.

Authors:  L Moretta; M Ferrarini; M C Mingari; A Moretta; S R Webb
Journal:  J Immunol       Date:  1976-12       Impact factor: 5.422

7.  Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens.

Authors:  R L Evans; T J Faldetta; R E Humphreys; D M Pratt; E J Yunis; S F Schlossman
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

8.  Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.

Authors:  L Moretta; S R Webb; C E Grossi; P M Lydyard; M D Cooper
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307

9.  Ia determinants on stimulated human T lymphocytes. Occurrence on mitogen- and antigen-activated T cells.

Authors:  H S Ko; S M Fu; R J Winchester; D T Yu; H G Kunkel
Journal:  J Exp Med       Date:  1979-08-01       Impact factor: 14.307

10.  Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures.

Authors:  J C Cerottini; H D Engers; H R Macdonald; T Brunner
Journal:  J Exp Med       Date:  1974-09-01       Impact factor: 14.307
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  16 in total

1.  Surface markers of resting and activated human T cells. Functional implications and experimental limits.

Authors:  M C Mingari; A Moretta; G Pantaleo; L Moretta
Journal:  Springer Semin Immunopathol       Date:  1982

2.  Surface markers of cloned human alloreactive T lymphocytes.

Authors:  X Chardonnens; Y Froment; M T Joye; M Jeannet
Journal:  Immunogenetics       Date:  1982-03       Impact factor: 2.846

3.  Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity.

Authors:  A Moretta; G Pantaleo; L Moretta; J C Cerottini; M C Mingari
Journal:  J Exp Med       Date:  1983-02-01       Impact factor: 14.307

Review 4.  Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98.

Authors:  Hang Thi Thu Nguyen; Didier Merlin
Journal:  Cell Mol Life Sci       Date:  2012-03-30       Impact factor: 9.261

5.  Functional heterogeneities among concanavalin A-activated OKT4+ and OKT8+ cells by using autologous erythrocyte rosette technique.

Authors:  S Takada; Y Ueda; Y Murakawa; N Suzuki; T Sakane
Journal:  J Clin Invest       Date:  1983-12       Impact factor: 14.808

6.  4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin.

Authors:  B Azzarone; H Suarez; M C Mingari; L Moretta; A S Fauci
Journal:  J Cell Biol       Date:  1984-03       Impact factor: 10.539

7.  Clonal heterogeneity in the requirement for T3, T4, and T8 molecules in human cytolytic T lymphocyte function.

Authors:  A Moretta; G Pantaleo; M C Mingari; L Moretta; J C Cerottini
Journal:  J Exp Med       Date:  1984-03-01       Impact factor: 14.307

8.  Differential expression of proteins in naïve and IL-2 stimulated primary human NK cells identified by global proteomic analysis.

Authors:  Weifeng Cao; Arvinder Kapur; Di Ma; Mildred Felder; Cameron O Scarlett; Manish S Patankar; Lingjun Li
Journal:  J Proteomics       Date:  2013-06-25       Impact factor: 4.044

9.  Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations.

Authors:  A Moretta; G Pantaleo; L Moretta; M C Mingari; J C Cerottini
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

10.  Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes.

Authors:  J H Kehrl; A S Fauci
Journal:  J Exp Med       Date:  1983-05-01       Impact factor: 14.307
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