| Literature DB >> 6439591 |
T Horiuchi, H Fujiki, M Suganuma, H Hakii, M Nakayasu, Y Hitotsuyanagi, N Aimi, S Sakai, Y Endo, K Shudo.
Abstract
Three olivoretins, A, B and C (isolated from Streptoverticillium olivoreticuli), which are O-methylated teleocidin B isomers, were found to be biologically inactive. A fourth olivoretin, D, which has a free hydroxyl group and is identical to one of the four teleocidin B isomers, teleocidin B-4 (teleocidin B of Hirata) was biologically active. These findings indicate that the free primary hydroxyl group of teleocidin B isomers is necessary for activity. The effect on biological activity of the structural difference between des-O-methylolivoretin B (teleocidin B-1) and des-O-methylolivoretin C was also studied.Entities:
Mesh：
Substances：
Year: 1984 PMID： 6439591
Source DB: PubMed Journal: Gan ISSN： 0016-450X