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Literature DB >> 6437072

Myofibroblast-like cells in human anterior capsular cataract.

Abstract

In six cases of anterior capsular cataract, cells present in the subcapsular zone were investigated. In addition to organelles previously described, the cells were found to contain 7 nm and 15 nm filaments, suggestive of actin and myosin. The cells varied in shape from elongated or flat to rounded. Maculae adhaerentes, gap junctions and basement membranes were present. It is concluded that these cells closely resemble myofibroblasts, by virtue of their cytology and behaviour. The significance of this observation, concerning hypotheses on the genesis of anterior capsular cataract is discussed.

Entities: Disease Gene Species

Mesh：

Year: 1984 PMID： 6437072 DOI： 10.1007/bf00695223

Source DB: PubMed Journal: Virchows Arch A Pathol Anat Histopathol ISSN： 0174-7398

26 in total

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23 in total

1. Temporal changes in MMP mRNA expression in the lens epithelium during anterior subcapsular cataract formation.

Authors: Zahra Nathu; Dhruva J Dwivedi; John R Reddan; Heather Sheardown; Peter J Margetts; Judith A West-Mays
Journal: Exp Eye Res Date: 2008-09-06 Impact factor: 3.467

2. Lens-specific expression of TGF-beta induces anterior subcapsular cataract formation in the absence of Smad3.

Authors: Alice Banh; Paula A Deschamps; Jack Gauldie; Paul A Overbeek; Jacob G Sivak; Judith A West-Mays
Journal: Invest Ophthalmol Vis Sci Date: 2006-08 Impact factor: 4.799

Review 3. Fibrosis in the lens. Sprouty regulation of TGFβ-signaling prevents lens EMT leading to cataract.

Authors: F J Lovicu; E H Shin; J W McAvoy
Journal: Exp Eye Res Date: 2015-05-21 Impact factor: 3.467

4. Cell types of secondary cataract: an immunohistochemical analysis with antibodies to cytoskeletal elements and macrophages.

Authors: M Uusitalo; T Kivelä
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1997-08 Impact factor: 3.117