Literature DB >> 6436449

Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa.

G Firnau, R Chirakal, E S Garnett.   

Abstract

A new synthesis is described for the routine production of 3,4-dihydroxy-6-[18F]fluoro-phenyl-L-alanine (6-[18F]fluoro-L-dopa). The reaction between [18F]fluorine gas and 3,4-dihydroxyphenyl-L-alanine (L-dopa) in liquid hydrogen fluoride gave 2-, 5-, and 6-[18F]fluoro-L-dopa. 6-[18F]Fluoro-L-dopa was isolated by reverse-phase high-pressure liquid chromatography. From 100 mCi [18F]F2, the method produces 3 mCi of 6-[18F]fluoro-L-dopa at the end of synthesis.

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Year:  1984        PMID： 6436449

Source DB:  PubMed          Journal:  J Nucl Med        ISSN： 0161-5505            Impact factor:   10.057


  10 in total

1.  Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography.

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2.  Syntheses of fluorinated amino acids: from the classical to the modern concept.

Authors:  V Tolman
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3.  A PROSTHETIC GROUP FOR THE RAPID INTRODUCTION OF FLUORINE INTO PEPTIDES AND FUNCTIONALIZED DRUGS.

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4.  Total Radiosynthesis: Thinking outside "the box".

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5.  Positron emission tomography (PET) imaging with (18)F-based radiotracers.

Authors:  Mian M Alauddin
Journal:  Am J Nucl Med Mol Imaging       Date:  2011-12-15

Review 6.  6-[18F]fluoro-L-DOPA: a well-established neurotracer with expanding application spectrum and strongly improved radiosyntheses.

Authors:  M Pretze; C Wängler; B Wängler
Journal:  Biomed Res Int       Date:  2014-05-28       Impact factor: 3.411

7.  Site-Selective Late-Stage Aromatic [18 F]Fluorination via Aryl Sulfonium Salts.

Authors:  Peng Xu; Da Zhao; Florian Berger; Aboubakr Hamad; Jens Rickmeier; Roland Petzold; Mykhailo Kondratiuk; Kostiantyn Bohdan; Tobias Ritter
Journal:  Angew Chem Int Ed Engl       Date:  2019-12-12       Impact factor: 15.336

8.  GMP production of 6-[18F]Fluoro-L-DOPA for PET/CT imaging by different synthetic routes: a three center experience.

Authors:  Valdemar L Andersen; Mikkel A Soerensen; Johan Hygum Dam; Niels Langkjaer; Henrik Petersen; Dirk Andreas Bender; Dan Fugloe; Tri Hien Viet Huynh
Journal:  EJNMMI Radiopharm Chem       Date:  2021-06-12

9.  Copper-catalyzed [18F]fluorination of (mesityl)(aryl)iodonium salts.

Authors:  Naoko Ichiishi; Allen F Brooks; Joseph J Topczewski; Melissa E Rodnick; Melanie S Sanford; Peter J H Scott
Journal:  Org Lett       Date:  2014-06-03       Impact factor: 6.005

Review 10.  Nucleophilic Synthesis of 6-l-[18F]FDOPA. Is Copper-Mediated Radiofluorination the Answer?

Authors:  Raisa N Krasikova
Journal:  Molecules       Date:  2020-09-23       Impact factor: 4.411
  10 in total

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