Literature DB >> 6430614

The distribution of microsomal and thyroglobulin antibody activity among the IgG subclasses.

A B Parkes, S M McLachlan, P Bird, B Rees Smith.   

Abstract

The IgG subclass distribution of autoantibodies to thyroglobulin (TgAb) and thyroid microsomes (MicAb) in 13 Hashimoto's sera has been investigated using an ELISA technique based on monoclonal anti-subclass antibodies. Considerable subclass restriction was observed with TgAb predominantly but not exclusively associated with IgG4 (mean %TgAb activity associated with IgG4 = 60%) and MicAb predominantly associated with IgG 1 (mean = 49%) and IgG4 (mean = 38%). The tendency for TgAb to be associated with IgG4 accorded with the weak complement fixing properties of this antibody whereas the association of MicAb with IgG1 was consistent with its complement fixing and cytotoxic properties.

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Year:  1984        PMID： 6430614      PMCID： PMC1536069     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  7 in total

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Authors:  H L Spiegelberg
Journal:  Adv Immunol       Date:  1974       Impact factor: 3.543

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Authors:  J B Natvig; H G Kunkel
Journal:  Adv Immunol       Date:  1973       Impact factor: 3.543

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Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

4.  Monoclonal antibodies (McAbs) to determinants on human gamma chains: properties of antibodies showing subclass restriction or subclass specificity.

Authors:  J Lowe; P Bird; D Hardie; R Jefferis; N R Ling
Journal:  Immunology       Date:  1982-10       Impact factor: 7.397

5.  IgG subclass distribution in organ specific autoantibodies. The relationship to complement fixing ability.

Authors:  B M Dean; G F Bottazzo; A G Cudworth
Journal:  Clin Exp Immunol       Date:  1983-04       Impact factor: 4.330

6.  An enzyme-linked immunoassay for thyroid microsomal antibodies.

Authors:  C W Schardt; S M McLachlan; J Matheson; B R Smith
Journal:  J Immunol Methods       Date:  1982-12-17       Impact factor: 2.303

7.  pH gradient elution of human IgG1, IgG2 and IgG4 from protein A-sepharose.

Authors:  R C Duhamel; P H Schur; K Brendel; E Meezan
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303
  7 in total
  21 in total

1.  Serum immunoglobulin G4 levels and Graves' disease phenotype.

Authors:  Carmen Sorina Martin; Anca Elena Sirbu; Minodora Andreea Betivoiu; Suzana Florea; Carmen Gabriela Barbu; Simona Vasilica Fica
Journal:  Endocrine       Date:  2016-11-07       Impact factor: 3.633

2.  IgG subclass distribution and relative functional affinity of anti-myeloperoxidase antibodies in systemic vasculitis at presentation and during follow-up.

Authors:  V L Esnault; D R Jayne; A P Weetman; C M Lockwood
Journal:  Immunology       Date:  1991-12       Impact factor: 7.397

3.  Thyroglobulin autoantibodies switch to immunoglobulin (Ig)G1 and IgG3 subclasses and preserve their restricted epitope pattern after 131I treatment for Graves' hyperthyroidism: the activity of autoimmune disease influences subclass distribution but not epitope pattern of autoantibodies.

Authors:  F Latrofa; D Ricci; L Montanelli; P Piaggi; B Mazzi; F Bianchi; F Brozzi; P Santini; E Fiore; M Marinò; M Tonacchera; P Vitti
Journal:  Clin Exp Immunol       Date:  2014-12       Impact factor: 4.330

4.  Relationship between autoantibody epitopic recognition and immunoglobulin gene usage.

Authors:  J Guo; R S Mcintosh; B Czarnocka; A P Weetman; B Rapoport; S M McLachlan
Journal:  Clin Exp Immunol       Date:  1998-02       Impact factor: 4.330

5.  Functional analysis of T and B cells from blood and thyroid tissue in Hashimoto's disease.

Authors:  S M McLachlan; G Proud; C A Pegg; F Clark; B Rees Smith
Journal:  Clin Exp Immunol       Date:  1985-03       Impact factor: 4.330

6.  Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ.

Authors:  G D Chazenbalk; S Portolano; D Russo; J S Hutchison; B Rapoport; S McLachlan
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

Review 7.  Genetic and epitopic analysis of thyroid peroxidase (TPO) autoantibodies: markers of the human thyroid autoimmune response.

Authors:  S M McLachlan; B Rapoport
Journal:  Clin Exp Immunol       Date:  1995-08       Impact factor: 4.330

8.  Predominance of IgG1 and IgG4 subclasses of anti-neutrophil cytoplasmic autoantibodies (ANCA) in patients with Wegener's granulomatosis and clinically related disorders.

Authors:  E Brouwer; J W Tervaert; G Horst; M G Huitema; M van der Giessen; P C Limburg; C G Kallenberg
Journal:  Clin Exp Immunol       Date:  1991-03       Impact factor: 4.330

9.  Recognition by recombinant autoimmune thyroid disease-derived Fab fragments of a dominant conformational epitope on human thyroid peroxidase.

Authors:  S Portolano; G D Chazenbalk; P Seto; J S Hutchison; B Rapoport; S M McLachlan
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

10.  IgG subclass distribution of thyroglobulin antibodies in patients with thyroid disease.

Authors:  P Caturegli; R C Kuppers; S Mariotti; C L Burek; A Pinchera; P W Ladenson; N R Rose
Journal:  Clin Exp Immunol       Date:  1994-12       Impact factor: 4.330
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