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Literature DB >> 6180976

Monoclonal antibodies (McAbs) to determinants on human gamma chains: properties of antibodies showing subclass restriction or subclass specificity.

J Lowe, P Bird, D Hardie, R Jefferis, N R Ling.

Abstract

Thirteen monoclonal antibodies (McAbs) showing subclass-specific and subclass-restricted reactivity to human IgG have been produced by the hybridoma technique. Their specificity has been defined by passive haemagglutination (HA) and haemagglutination-inhibition (HAI) assays using a large panel pf purified IgG paraproteins of known subclass. Their use in assaying human IgG subclasses in radial immunodiffusion (RID) and in purifying human subclasses by both positive and negative immunoabsorption chromatography is illustrated.

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Year: 1982 PMID： 6180976 PMCID： PMC1555448

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

15 in total

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47 in total

1. IgG subclass-containing cells around the lymph follicle in the human intestine.

Authors: M Iizuka; M Chiba; N Ishii; O Masamune
Journal: Gastroenterol Jpn Date: 1992-10

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Journal: Immunology Date: 1987-09 Impact factor: 7.397

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