Literature DB >> 6430314

Differential transplacental binding of valproic acid: influence of free fatty acids.

F Albani, R Riva, M Contin, A Baruzzi, M Altomare, G P Merlini, E Perucca.   

Abstract

The unbound fraction of valproic acid (VPA) was found to be significantly lower in cord serum (6.0 +/- 0.8%) than in maternal serum collected before oxytocin (12.2 +/- 2.7%) or after delivery (9.9 +/- 2.3%). The difference was probably due to the concentration of free fatty acids (acting as displacing agents) being higher in maternal serum. The transplacental binding gradient explains the clinical observation that total VPA levels at delivery are higher in the newborn than in the mother.

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Year:  1984        PMID： 6430314      PMCID： PMC1463429          DOI： 10.1111/j.1365-2125.1984.tb02414.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  12 in total

1.  Serum protein binding of valproic acid and its displacement by palmitic acid in vitro.

Authors:  A Monks; A Richens
Journal:  Br J Clin Pharmacol       Date:  1979-08       Impact factor: 4.335

2.  Transplacental passage and half-life of sodium valproate in infants born to epileptic mothers.

Authors:  S Kaneko; K Otani; Y Fukushima; T Sato; Y Nomura; Y Ogawa
Journal:  Br J Clin Pharmacol       Date:  1983-04       Impact factor: 4.335

3.  Altered drug binding to serum proteins in pregnant women: therapeutic relevance.

Authors:  E Perucca; M Ruprah; A Richens
Journal:  J R Soc Med       Date:  1981-06       Impact factor: 5.344

4.  Serum protein binding of drugs and bilirubin in newborn infants and their mothers.

Authors:  C Hamar; G Levy
Journal:  Clin Pharmacol Ther       Date:  1980-07       Impact factor: 6.875

5.  Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies.

Authors:  C B Laurell
Journal:  Anal Biochem       Date:  1966-04       Impact factor: 3.365

6.  Transmission of valproic acid (Depakene) across the placenta: half-life of the drug in mother and baby.

Authors:  R G Dickinson; R C Harland; R K Lynn; W B Smith; N Gerber
Journal:  J Pediatr       Date:  1979-05       Impact factor: 4.406

7.  Diazepam plasma binding in the perinatal period: influence of nonesterified fatty acids.

Authors:  M J Ridd; K F Brown; R G Moore; W G McBride; R L Nation
Journal:  Eur J Clin Pharmacol       Date:  1982       Impact factor: 2.953

8.  Determination of unbound valproic acid concentration in plasma by equilibrium dialysis and gas--liquid chromatography: methodological aspects and observations in epileptic patients.

Authors:  R Riva; F Albani; A Baruzzi; I Galvani; E Perucca
Journal:  Ther Drug Monit       Date:  1982       Impact factor: 3.681

9.  Placental transfer of anticonvulsants (phenobarbital, phenytoin, valproic acid) and the elimination from neonates.

Authors:  T Ishizaki; K Yokochi; K Chiba; T Tabuchi; T Wagatsuma
Journal:  Pediatr Pharmacol (New York)       Date:  1981

10.  Free fraction of valproic acid: in vitro time-dependent increase and correlation with free fatty acid concentration in human plasma and serum.

Authors:  F Albani; R Riva; G Procaccianti; A Baruzzi; E Perucca
Journal:  Epilepsia       Date:  1983-02       Impact factor: 5.864
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  6 in total

1.  The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida.

Authors:  J G Omtzigt; H Nau; F J Los; L Pijpers; D Lindhout
Journal:  Eur J Clin Pharmacol       Date:  1992       Impact factor: 2.953

Review 2.  The treatment of hypertension in pregnancy. Clinical pharmacokinetic considerations.

Authors:  C Knott
Journal:  Clin Pharmacokinet       Date:  1991-10       Impact factor: 6.447

Review 3.  Therapeutic drug monitoring in pregnancy: rationale and current status.

Authors:  C Knott; F Reynolds
Journal:  Clin Pharmacokinet       Date:  1990-12       Impact factor: 6.447

4.  Placental transfer and neonatal elimination of mono-unsaturated metabolites of valproic acid.

Authors:  T Kondo; K Otani; T Hirano; S Kaneko
Journal:  Br J Clin Pharmacol       Date:  1987-09       Impact factor: 4.335

5.  Valproic acid during pregnancy decrease the number of spermatogenic cells and testicular volume in the offspring of mice: Stereological quantification.

Authors:  Daniel Conei; Mariana Rojas; Luis Santamaría; Jennie Risopatrón
Journal:  Histol Histopathol       Date:  2021-10-19       Impact factor: 2.303

6.  Milk transfer and toxicokinetics of valproic Acid in lactating cynomolgus monkeys.

Authors:  Jong-Hwa Lee; Wook-Joon Yu; Eun Ju Jeong; Moon-Koo Chung
Journal:  Toxicol Res       Date:  2013-03
  6 in total

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