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Literature DB >> 6430084

A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes.

Abstract

Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the "all-possible-pairs" method.

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Year: 1984 PMID： 6430084 DOI： 10.1002/ajmg.1320180117

Source DB: PubMed Journal: Am J Med Genet ISSN： 0148-7299

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Cited

13 in total

1. Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci.

Authors: W M Sribney; M Swift
Journal: Am J Hum Genet Date: 1992-10 Impact factor: 11.025

2. Analysis of affected sib pairs, with covariates--with and without constraints.

Authors: C M Greenwood; S B Bull
Journal: Am J Hum Genet Date: 1999-03 Impact factor: 11.025

3. Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata.

Authors: Amalia Martinez-Mir; Abraham Zlotogorski; Derek Gordon; Lynn Petukhova; Jianhong Mo; T Conrad Gilliam; Douglas Londono; Chad Haynes; Jurg Ott; Maria Hordinsky; Krassimira Nanova; David Norris; Vera Price; Madeleine Duvic; Angela M Christiano
Journal: Am J Hum Genet Date: 2007-01-05 Impact factor: 11.025

Review 4. Current perspectives on the genetics of unipolar depression.

Authors: S O Moldin; T Reich; J P Rice
Journal: Behav Genet Date: 1991-05 Impact factor: 2.805

Review 5. Cutting a Gordian knot in the linkage analysis of complex human traits.

Authors: J Ott
Journal: Am J Hum Genet Date: 1990-02 Impact factor: 11.025

6. Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data.

Authors: L Abel; B Müller-Myhsok
Journal: Am J Hum Genet Date: 1998-08 Impact factor: 11.025

A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes.

1. Power of sib-pair and sib-trio linkage analysis with assortative mating and multiple disease loci.

2. Analysis of affected sib pairs, with covariates--with and without constraints.

3. Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata.

Review 4. Current perspectives on the genetics of unipolar depression.

Review 5. Cutting a Gordian knot in the linkage analysis of complex human traits.

6. Robustness and power of the maximum-likelihood-binomial and maximum-likelihood-score methods, in multipoint linkage analysis of affected-sibship data.

7. Genome scan for human obesity and linkage to markers in 20q13.

8. Simple, robust linkage tests for affected sibs.

9. Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene.

10. Non-concordance by gender for schizophrenia and related disorders in sibships.