Literature DB >> 6425894

Long-lasting single-dose tolerance to neurologic deficits induced by diazepam.

S A Henauer, E J Gallaher, L E Hollister.   

Abstract

Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test. Diazepam suspended in corn oil was administered orally in doses 5-20 mg/kg. Tolerance was found following a second administration of diazepam 24 h after a first dose. It decayed gradually over 4-5 weeks. Hence tolerance persists considerably longer than measurable amounts of diazepam or its metabolites are likely to be present in mice.

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Year:  1984        PMID： 6425894     DOI： 10.1007/bf00427765

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  10 in total

1.  Effects of repeated administration of chlordiazepoxide on spontaneous locomotor activity in mice.

Authors:  M Sansone
Journal:  Psychopharmacology (Berl)       Date:  1979       Impact factor: 4.530

2.  A note on a simple apparatus for detecting neurological deficit in rats and mice.

Authors:  N W DUNHAM; T S MIYA
Journal:  J Am Pharm Assoc Am Pharm Assoc       Date:  1957-03

3.  Rapid development of tolerance to the sedative effects of lorazepam and triazolam in rats.

Authors:  S E File
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

Review 4.  Receptor alterations and drug tolerance.

Authors:  D H Overstreet; H I Yamamura
Journal:  Life Sci       Date:  1979-11-26       Impact factor: 5.037

5.  A comparative study of certain pharmacologic responses following acute and chronic administrations of chlordiazepoxide.

Authors:  M E Goldberg; A A Manian; D H Efron
Journal:  Life Sci       Date:  1967-03-01       Impact factor: 5.037

Review 6.  Clinical pharmacokinetics of diazepam.

Authors:  M Mandelli; G Tognoni; S Garattini
Journal:  Clin Pharmacokinet       Date:  1978 Jan-Feb       Impact factor: 6.447

7.  Diazepam, ethanol and drug metabolizing enzymes in rat liver.

Authors:  M S Vorne; J O Puolakka; J E Idänpään-Heikkilä
Journal:  Arch Int Pharmacodyn Ther       Date:  1975-08

8.  Pharmacological activities of clobazam and diazepam in the rat: relation to drug brain levels.

Authors:  S Caccia; M Carli; S Garattini; E Poggesi; R Rech; R Samanin
Journal:  Arch Int Pharmacodyn Ther       Date:  1980-02

9.  Tolerance during chronic benzodiazepine treatment associated with decreased receptor binding.

Authors:  H C Rosenberg; T H Chiu
Journal:  Eur J Pharmacol       Date:  1981-04-09       Impact factor: 4.432

10.  Influence of age and previous use of diazepam dosage required for endoscopy.

Authors:  H G Giles; S M MacLeod; J R Wright; E M Sellers
Journal:  Can Med Assoc J       Date:  1978-03-04       Impact factor: 8.262
  10 in total
  4 in total

1.  Mouse lines selected for genetic differences in diazepam sensitivity.

Authors:  E J Gallaher; L E Hollister; S E Gionet; J C Crabbe
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Comparison of behavioral effects after single and repeated administrations of four benzodiazepines in three mice behavioral models.

Authors:  M Bourin; M Hascoet; B Mansouri; M C Colombel; J Bradwejn
Journal:  J Psychiatry Neurosci       Date:  1992-06       Impact factor: 6.186

3.  Dose-dependent impairment in the performance of a go-no go successive discrimination by chlordiazepoxide.

Authors:  S O Cole; A Michaleski
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure.

Authors:  J Dingemanse; F A Sollie; D D Breimer; M Danhof
Journal:  J Pharmacokinet Biopharm       Date:  1988-04
  4 in total

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