Literature DB >> 6423597

Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity.

G Werner, H Hagenmaier, H Drautz, A Baumgartner, H Zähner.   

Abstract

The bafilomycins A1, A2, B1, B2, C1 and C2, a new type of macrolide antibiotics with a 16-membered lactone ring, were isolated from the fermentation broth of three Streptomyces griseus strains (TU 1922, TU 2437, TU 2599) by ethyl acetate extraction and column chromatography on silica gel. The bafilomycins exhibit activity against Gram-positive bacteria and fungi. Physico-chemical data, chemical structures and biological activities are reported.

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Year:  1984        PMID： 6423597     DOI： 10.7164/antibiotics.37.110

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  60 in total

1.  Identification of the biosynthetic gene cluster for the antibiotic polyketide L-155,175 in Streptomyces hygroscopicus.

Authors:  Eun Young Kim; Jae Woo Han; Jee Yeon Lee; Beom Seok Kim
Journal:  Folia Microbiol (Praha)       Date:  2012-06-06       Impact factor: 2.099

2.  The cytotoxic necrotizing factors from Yersinia pseudotuberculosis and from Escherichia coli bind to different cellular receptors but take the same route to the cytosol.

Authors:  Britta Blumenthal; Claudia Hoffmann; Klaus Aktories; Steffen Backert; Gudula Schmidt
Journal:  Infect Immun       Date:  2007-04-16       Impact factor: 3.441

3.  Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp.

Authors:  George R Pettit; Rui Tan; Robin K Pettit; Thomas H Smith; Song Feng; Dennis L Doubek; Linda Richert; John Hamblin; Christine Weber; Jean-Charles Chapuis
Journal:  J Nat Prod       Date:  2007-07-04       Impact factor: 4.050

4.  Chlamydia muridarum infection elicits a beta interferon response in murine oviduct epithelial cells dependent on interferon regulatory factor 3 and TRIF.

Authors:  Wilbert A Derbigny; Soon-Cheol Hong; Micah S Kerr; M'hamed Temkit; Raymond M Johnson
Journal:  Infect Immun       Date:  2006-12-18       Impact factor: 3.441

5.  Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin.

Authors:  Miroslav Petrícek; Katerina Petrícková; Libor Havlícek; Jürgen Felsberg
Journal:  J Bacteriol       Date:  2006-07       Impact factor: 3.490

6.  Bafilomycin A1 and intracellular multiplication of Legionella pneumophila.

Authors:  L Cattani; P Goldoni; M C Pastoris; L Sinibaldi; N Orsi
Journal:  Antimicrob Agents Chemother       Date:  1997-01       Impact factor: 5.191

7.  Additional congeners of the macrolide neaumycin: structure revision and biological activity.

Authors:  Matteo Simone; Sonia I Maffioli; Arianna Tocchetti; Stefano Tretter; Monica Cattaneo; Ida Biunno; Eleonora Gaspari; Stefano Donadio
Journal:  J Antibiot (Tokyo)       Date:  2015-01-14       Impact factor: 2.649

8.  V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer.

Authors:  Bradleigh Whitton; Haruko Okamoto; Matthew Rose-Zerilli; Graham Packham; Simon J Crabb
Journal:  Mol Cancer Ther       Date:  2021-02-09       Impact factor: 6.261

9.  "Function-first" lead discovery: mode of action profiling of natural product libraries using image-based screening.

Authors:  Christopher J Schulze; Walter M Bray; Marcos H Woerhmann; Joshua Stuart; R Scott Lokey; Roger G Linington
Journal:  Chem Biol       Date:  2013-02-21

10.  Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072.

Authors:  Keisuke Kobayashi; Takashi Fukuda; Takeo Usui; Yuko Kurihara; Akihiko Kanamoto; Hiroshi Tomoda
Journal:  J Antibiot (Tokyo)       Date:  2014-08-06       Impact factor: 2.649
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