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Literature DB >> 6423340

Discrepancies between in vitro activity of and in vivo response to antimicrobial agents.

Abstract

The correlation between in vitro antimicrobial activity and the in vivo response to antimicrobial therapy is affected by multiple host factors, the site and nature of the infection, and the pharmacokinetics of the antimicrobial and its penetration into areas of infection. In certain instances, discrepancies are also caused by methodologically-related variables of in vitro susceptibility tests. Examples of discrepancies between in vitro and in vivo response to antimicrobial are discussed.

Entities: Disease

Mesh：

Substances：

Year: 1983 PMID： 6423340 DOI： 10.1016/0732-8893(83)90029-9

Source DB: PubMed Journal: Diagn Microbiol Infect Dis ISSN： 0732-8893 Impact factor: 2.803

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Cited

14 in total

1. Efficacy of SCH39304 in murine cryptococcosis.

Authors: B I Restrepo; J Ahrens; J R Graybill
Journal: Antimicrob Agents Chemother Date: 1989-08 Impact factor: 5.191

2. An infectious disease and pharmacokinetic perspective on oral antibiotic treatment of uncomplicated urinary tract infections due to multidrug-resistant Gram-negative uropathogens: the importance of urinary antibiotic concentrations and urinary pH.

Authors: B A Cunha
Journal: Eur J Clin Microbiol Infect Dis Date: 2016-02-09 Impact factor: 3.267

Review 3. Serum bactericidal test.

Authors: C W Stratton
Journal: Clin Microbiol Rev Date: 1988-01 Impact factor: 26.132

Discrepancies between in vitro activity of and in vivo response to antimicrobial agents.

1. Efficacy of SCH39304 in murine cryptococcosis.

2. An infectious disease and pharmacokinetic perspective on oral antibiotic treatment of uncomplicated urinary tract infections due to multidrug-resistant Gram-negative uropathogens: the importance of urinary antibiotic concentrations and urinary pH.

Review 3. Serum bactericidal test.

4. In vitro activity of BMY-28142 against pediatric pathogens, including isolates from cystic fibrosis sputum.

Review 5. Standardization of the serum bactericidal test and its relationship to levels of antimicrobial agents.

6. Susceptibility to tobramycin determined by a modified agar dilution method with a high inoculum.

Review 7. Ceforanide. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy.

Review 8. Considerations in dosage selection for third generation cephalosporins.

9. Treatment of murine cryptococcal meningitis with an SCH 39304-amphotericin B combination.

10. Aminoglycoside resistance among Pseudomonas aeruginosa isolates with an unusual disk diffusion antibiogram.