Literature DB >> 103560

Antibodies reacting with ribosomal ribonucleoprotein in connective tissue diseases.

K Miyachi, E M Tan.   

Abstract

Precipitating antibody to an antigen present in cytoplasm was detected in the sera of 7 patients with systemic lupus erythematosus, 1 patient with an overlap toid arthritis, and 1 patient with mixed connective tissue disease. By physicochemical and enzymatic studies, the antigen was shown to have the properties of ribosomal ribonucleoprotein (gamma-RNP). Cytoplasmic staining in immunofluorescence was observed with all the 9 sera containing antibodies to gamma-RNP. In certain cases, cytoplasmic staining was associated with nucleolar staining. Antibody to gamma-RNP is different in immunologic specificity and clinical significance from antibody to nuclear RNP and is present primarily in patients with systemic lupus erythematosus.

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Year:  1979        PMID： 103560     DOI： 10.1002/art.1780220114

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  17 in total

1.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

2.  Characterisation of centromere (kinetochore) antigen reactive with sera of patients with a scleroderma variant (CREST syndrome).

Authors:  M Nishikai; Y Okano; H Yamashita; M Watanabe
Journal:  Ann Rheum Dis       Date:  1984-12       Impact factor: 19.103

3.  Preciitating antibodies to mitochondrial antigens in patients with primary biliary cirrhosis.

Authors:  K Miyachi; R C Gupta; E R Dickson; E M Tan
Journal:  Clin Exp Immunol       Date:  1980-03       Impact factor: 4.330

4.  Multi-center evaluation of autoantibodies to the major ribosomal P C22 epitope.

Authors:  M Mahler; N Agmon-Levin; M van Liempt; Y Shoenfeld; A Waka; F Hiepe; A Swart; I Gürtler; M J Fritzler
Journal:  Rheumatol Int       Date:  2010-12-08       Impact factor: 2.631

5.  Anti-ribosomal ribonucleoprotein autoantibodies in systemic lupus erythematosus.

Authors:  P L Meroni; G de Bartolo; W Barcellini; P S Riboldi; R Basile; C Betterle; C Zanussi
Journal:  J Clin Immunol       Date:  1984-01       Impact factor: 8.317

Review 6.  Diversity and origin of rheumatologic autoantibodies.

Authors:  M J Fritzler; M Salazar
Journal:  Clin Microbiol Rev       Date:  1991-07       Impact factor: 26.132

7.  Autoantibody to ribosomes and systemic lupus erythematosus.

Authors:  J P Mathy; R Baum; B H Toh
Journal:  Clin Exp Immunol       Date:  1980-07       Impact factor: 4.330

8.  In vivo anti-nuclear antibodies in epithelial biopsies in SLE and other connective tissue diseases.

Authors:  J V Wells; J Webb; M Van Deventer; B Fry; K M Pollard; J Raftos; W Monk; D S Nelson
Journal:  Clin Exp Immunol       Date:  1979-12       Impact factor: 4.330

9.  Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

Authors:  E A Lerner; M R Lerner; C A Janeway; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

10.  Limited reliability of the indirect immunofluorescence technique for the detection of anti-Rib-P antibodies.

Authors:  Michael Mahler; Jennifer T Ngo; Johannes Schulte-Pelkum; Tanja Luettich; Marvin J Fritzler
Journal:  Arthritis Res Ther       Date:  2008-11-11       Impact factor: 5.156
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