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Literature DB >> 6420347

Immunization with Pseudomonas aeruginosa high-molecular-weight polysaccharides prevents death from Pseudomonas burn infections in mice.

Abstract

High-molecular-weight polysaccharides from the extracellular slime of Pseudomonas aeruginosa were evaluated as immunogens in Pseudomonas burn infections in mice. Immunization with immunotype 1 or 2 polysaccharides induced a strong immunotype-specific and weak cross-reactive antibody response but protected mice against burn infections caused by either immunotype. Passive protection was provided by rabbit antiserum to immunotype 1 polysaccharide against burn infection by the homologous organism. Pseudomonas high-molecular-weight polysaccharides are potentially effective vaccines in burn infections.

Entities: Chemical Disease Species

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Year: 1984 PMID： 6420347 PMCID： PMC264367 DOI： 10.1128/iai.43.2.759-760.1984

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

9 in total

1. Passive protection by antitoxin in experimental Pseudomonas aeruginosa burn infections.

Authors: O R Pavlovskis; M Pollack; L T Callahan; B H Iglewski
Journal: Infect Immun Date: 1977-12 Impact factor: 3.441

2. New immunotype schema for Pseudomonas aeruginosa based on protective antigens.

Authors: M W Fisher; H B Devlin; F J Gnabasik
Journal: J Bacteriol Date: 1969-05 Impact factor: 3.490

3. Cross-protection by Pseudomonas aeruginosa polysaccharides.

Authors: G B Pier
Journal: Infect Immun Date: 1982-12 Impact factor: 3.441

4. Isolation and characterization of a high-molecular-weight polysaccharide from the slime of Pseudomonas aeruginosa.

Authors: G B Pier; H F Sidberry; S Zolyomi; J C Sadoff
Journal: Infect Immun Date: 1978-12 Impact factor: 3.441

5. Protective immunity induced in mice by immunization with high-molecular-weight polysaccharide from Pseudomonas aeruginosa.

Authors: G B Pier; H F Sidberry; J C Sadoff
Journal: Infect Immun Date: 1978-12 Impact factor: 3.441

6. Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: description of a burned mouse model.

Authors: D D Stieritz; I A Holder
Journal: J Infect Dis Date: 1975-06 Impact factor: 5.226

5 in total

1. Immunochemical and biochemical analysis of the polyvalent Pseudomonas aeruginosa vaccine PEV.

Authors: S MacIntyre; T McVeigh; P Owen
Journal: Infect Immun Date: 1986-02 Impact factor: 3.441

2. Structural analysis and immunogenicity of Pseudomonas aeruginosa immunotype 2 high molecular weight polysaccharide.

Authors: G B Pier; S E Bennett
Journal: J Clin Invest Date: 1986-02 Impact factor: 14.808

3. Smooth lipopolysaccharide is the major protective antigen for mice in the surface extract from IATS serotype 6 contributing to the polyvalent Pseudomonas aeruginosa vaccine PEV.

Authors: S MacIntyre; R Lucken; P Owen
Journal: Infect Immun Date: 1986-04 Impact factor: 3.441

4. Specificity and function of murine monoclonal antibodies and immunization-induced human polyclonal antibodies to lipopolysaccharide subtypes of Pseudomonas aeruginosa serogroup 06.

Authors: G B Pier; N L Koles; G Meluleni; K Hatano; M Pollack
Journal: Infect Immun Date: 1994-04 Impact factor: 3.441

5. Complex serology and immune response of mice to variant high-molecular-weight O polysaccharides isolated from Pseudomonas aeruginosa serogroup O2 strains.

Authors: K Hatano; G B Pier
Journal: Infect Immun Date: 1998-08 Impact factor: 3.441