Literature DB >> 6419731

The storage products in genetic and swainsonine-induced human mannosidosis.

I Cenci di Bello, P Dorling, B Winchester.   

Abstract

Swainsonine induces the accumulation of mannose-rich oligosaccharides in human fibroblasts. The composition of the storage products shows that swainsonine completely inhibits lysosomal alpha-D-mannosidase and alters processing of glycoproteins by inhibiting Golgi alpha-D-mannosidase II. Comparison of the storage products in genetic and swainsonine-induced mannosidosis suggests that human fibroblasts contain a lysosomal alpha-D-mannosidase that is unaffected in genetic mannosidosis.

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Year:  1983        PMID： 6419731      PMCID： PMC1152453          DOI： 10.1042/bj2150693

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Evidence that the mutant enzyme in fibroblasts of a patient with mannosidosis does not crossreact with antiserum raised against normal acidic alpha-D-mannosidase.

Authors:  L J Burditt; K A Chotai; B G Winchester
Journal:  FEBS Lett       Date:  1978-07-15       Impact factor: 4.124

2.  Swainsonine inhibits the biosynthesis of complex glycoproteins by inhibition of Golgi mannosidase II.

Authors:  D R Tulsiani; T M Harris; O Touster
Journal:  J Biol Chem       Date:  1982-07-25       Impact factor: 5.157

3.  Loco intoxication: indolizidine alkaloids of spotted locoweed (Astragalus lentiginosus).

Authors:  R J Molyneux; L F James
Journal:  Science       Date:  1982-04-09       Impact factor: 47.728

4.  Improved thin-layer chromatographic method in the diagnosis of mannosidosis.

Authors:  R B Friedman; M A Williams; H W Moser; E H Kolodny
Journal:  Clin Chem       Date:  1978-09       Impact factor: 8.327

5.  Urinary oligosaccharides of mannosidosis.

Authors:  K Yamashita; Y Tachibana; K Mihara; S Okada; H Yabuuchi; A Kobata
Journal:  J Biol Chem       Date:  1980-06-10       Impact factor: 5.157

6.  alpha-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.

Authors:  D R Tulsiani; S C Hubbard; P W Robbins; O Touster
Journal:  J Biol Chem       Date:  1982-04-10       Impact factor: 5.157

7.  Swainsonine prevents the processing of the oligosaccharide chains of influenza virus hemagglutinin.

Authors:  A D Elbein; P R Dorling; K Vosbeck; M Horisberger
Journal:  J Biol Chem       Date:  1982-02-25       Impact factor: 5.157

8.  Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.

Authors:  P R Dorling; C R Huxtable; S M Colegate
Journal:  Biochem J       Date:  1980-11-01       Impact factor: 3.857

9.  Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.

Authors:  P R Dorling; C R Huxtable; P Vogel
Journal:  Neuropathol Appl Neurobiol       Date:  1978 Jul-Aug       Impact factor: 8.090

10.  Swainsonine: an inhibitor of glycoprotein processing.

Authors:  A D Elbein; R Solf; P R Dorling; K Vosbeck
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205
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  16 in total

1.  Properties of baby-hamster kidney (BHK) cells treated with Swainsonine, an inhibitor of glycoprotein processing. Comparison with ricin-resistant BHK-cell mutants.

Authors:  L Foddy; J Feeney; R C Hughes
Journal:  Biochem J       Date:  1986-02-01       Impact factor: 3.857

2.  Glycoprotein metabolism in normal and beta-mannosidase-deficient cultured goat skin fibroblasts.

Authors:  L W Hancock; M Z Jones; G Dawson
Journal:  Biochem J       Date:  1986-02-15       Impact factor: 3.857

3.  Canine alpha-L-fucosidase in relation to the enzymic defect and storage products in canine fucosidosis.

Authors:  C Barker; A Dell; M Rogers; J A Alhadeff; B Winchester
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

4.  Effects of the alpha-mannosidase inhibitors, 1,4-dideoxy-1,4-imino-D-mannitol and swainsonine, on glycoprotein catabolism in cultured macrophages.

Authors:  P F Daniel; D S Newburg; N E O'Neil; P W Smith; G W Fleet
Journal:  Glycoconj J       Date:  1989       Impact factor: 2.916

5.  Inhibition of alpha-L-fucosidase by derivatives of deoxyfuconojirimycin and deoxymannojirimycin.

Authors:  B Winchester; C Barker; S Baines; G S Jacob; S K Namgoong; G Fleet
Journal:  Biochem J       Date:  1990-01-01       Impact factor: 3.857

6.  Isolation and Characterization of Swainsonine from Texas Locoweed (Astragalus emoryanus).

Authors:  D Davis; P Schwarz; T Hernandez; M Mitchell; B Warnock; A D Elbein
Journal:  Plant Physiol       Date:  1984-12       Impact factor: 8.340

7.  The structural basis of the inhibition of human alpha-mannosidases by azafuranose analogues of mannose.

Authors:  B Winchester; S al Daher; N C Carpenter; I Cenci di Bello; S S Choi; A J Fairbanks; G W Fleet
Journal:  Biochem J       Date:  1993-03-15       Impact factor: 3.857

8.  The substrate-specificity of human lysosomal alpha-D-mannosidase in relation to genetic alpha-mannosidosis.

Authors:  S al Daher; R de Gasperi; P Daniel; N Hall; C D Warren; B Winchester
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857

9.  Structure-activity relationship of swainsonine. Inhibition of human alpha-mannosidases by swainsonine analogues.

Authors:  I Cenci di Bello; G Fleet; S K Namgoong; K Tadano; B Winchester
Journal:  Biochem J       Date:  1989-05-01       Impact factor: 3.857

10.  Structural analysis of the major urinary oligosaccharides in feline alpha-mannosidosis.

Authors:  D Abraham; P Daniel; A Dell; J Oates; R Sidebotham; B Winchester
Journal:  Biochem J       Date:  1986-02-01       Impact factor: 3.857
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