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Literature DB >> 6786280

Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens.

P R Dorling, C R Huxtable, S M Colegate.

Abstract

An indolizidine alkaloid (swainsonine) was isolated from the plant Swainsona canescens. Swainsonine is a specific and potent inhibitor of alpha-mannosidase (EC 3.2.1.24) and when administered to animals produces a phenocopy of the genetically based lysosomal storage disease, mannosidosis. Evidence is presented to suggest that swainsonine is a reversible active site-directed inhibitor of lysosomal alpha-mannosidase.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6786280 PMCID： PMC1162258 DOI： 10.1042/bj1910649

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

5 in total

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Authors: G D Smith; D V Roberts; P W Kuchel
Journal: Biochim Biophys Acta Date: 1975-01-23

2. On the inhibition of beta-N-acetyl-D-glucosaminidase by 2-acetamido-2-deoxy-D-glucono-(1-5)-lactone.

Authors: D H Leaback
Journal: Biochem Biophys Res Commun Date: 1968-09-30 Impact factor: 3.575

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Authors: N C Phillips; D Robinson; B G Winchester
Journal: Clin Chim Acta Date: 1974-08-30 Impact factor: 3.786

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Authors: N C Phillips; D Robinson; B G Winchester
Journal: Biochem J Date: 1976-03-01 Impact factor: 3.857

5. Lysosomal storage in Swainsona spp. toxicosis: an induced mannosidosis.

Authors: P R Dorling; C R Huxtable; P Vogel
Journal: Neuropathol Appl Neurobiol Date: 1978 Jul-Aug Impact factor: 8.090

5 in total

51 in total

1. Swainsonine as a lysosomal toxin affects dopaminergic neurons.

Authors: Qinfan Li; Yingzi Wang; Rudolf Moldzio; Weimin Lin; Wolf-Dieter Rausch
Journal: J Neural Transm (Vienna) Date: 2012-06-24 Impact factor: 3.575

2. Inactivation of solubilised fusicoccin-binding sites by endogenous plant hydrolases.

Authors: P Aducci; A Ballio; L Fiorucci; E Simonetti
Journal: Planta Date: 1984-04 Impact factor: 4.116

3. Effects of Elevated CO₂ on the Swainsonine Chemotypes of Astragalus lentiginosus and Astragalus mollissimus.

Authors: Daniel Cook; Dale R Gardner; James A Pfister; Clinton A Stonecipher; Joseph G Robins; Jack A Morgan
Journal: J Chem Ecol Date: 2017-02-11 Impact factor: 2.626

4. Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.

Authors: A Taraboulos; M Rogers; D R Borchelt; M P McKinley; M Scott; D Serban; S B Prusiner
Journal: Proc Natl Acad Sci U S A Date: 1990-11 Impact factor: 11.205

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Authors: S Kornfeld
Journal: J Clin Invest Date: 1986-01 Impact factor: 14.808

6. Molecular and biochemical characterization of alpha-glucosidase and alpha-mannosidase and their clustered genes from the thermoacidophilic archaeon Picrophilus torridus.

Authors: Angel Angelov; Mateusz Putyrski; Wolfgang Liebl
Journal: J Bacteriol Date: 2006-10 Impact factor: 3.490